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Tbio
MAP1LC3A
Microtubule-associated proteins 1A/1B light chain 3A

Protein Summary
Description
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360668
  • ENSP00000353886
  • ENSG00000101460
  • ENST00000374837
  • ENSP00000363970
  • ENST00000397709
  • ENSP00000380821

Symbol
  • LC3
  • LC3A
  • ATG8E
  • MAP1ALC3
  • MAP1BLC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.83
small molecule perturbation
0.77
cellular component
0.7
interacting protein
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.35   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 1228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.35   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 1228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
ATG7
Tchem
Novelty:  0.00120728
Score:  0.997
Data Source:  STRINGDB
ATG3
Tbio
Novelty:  0.00541077
Score:  0.996
Data Source:  STRINGDB
ATG4B
Tchem
Family:  Enzyme
Novelty:  0.0088416
Score:  0.995
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.993
Data Source:  STRINGDB
SQSTM1
Tbio
Novelty:  0.00100555
Score:  0.992
Data Source:  STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.992
Data Source:  Reactome,STRINGDB
ATG12
Tbio
Novelty:  0.00304298
Score:  0.989
Data Source:  Reactome,STRINGDB
ATG4A
Tbio
Family:  Enzyme
Novelty:  0.04073485
Score:  0.986
Data Source:  STRINGDB
ATG16L1
Tbio
Novelty:  0.0031765
Score:  0.985
Data Source:  STRINGDB
WIPI2
Tbio
Novelty:  0.02685992
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitophagy
Reactome
Pink/Parkin Mediated Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitophagy
Pink/Parkin Mediated Mitophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
4
7
97.2
glomerular filtration rate
3
3
3
94.1
3
2
0
1.8
90.8
suntan
1
1
1
88.4
sex hormone-binding globulin measurement
4
2
4
87.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
97.2
glomerular filtration rate
3
94.1
0
1.8
90.8
suntan
1
88.4
sex hormone-binding globulin measurement
4
87.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1 light chain 3 alpha
VGNC:14258
744937
Mouse
MGI:1915661
66734
Rat
RGD:735183
362245
Dog
microtubule associated protein 1 light chain 3 alpha
VGNC:54324
477201
Horse
microtubule associated protein 1 light chain 3 alpha
VGNC:19923
100146217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1 light chain 3 alpha
Mouse
Rat
Dog
microtubule associated protein 1 light chain 3 alpha
Horse
microtubule associated protein 1 light chain 3 alpha
Publication Statistics
PubMed Score 284.35
PubMed score by year
PubTator Score 898.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title