Tbio PIGU Phosphatidylinositol glycan anchor biosynthesis class U protein

Protein Summary

Description

Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H490
• Q7Z489
• Q8N2F2

Gene Name

• PIGU

Ensembl ID

• ENST00000217446
• ENSP00000217446
• ENSG00000101464
• ENST00000374820
• ENSP00000363953

Symbol

• CDC91L1
• GAB1
• CDC91L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
transcription factor	0.87
cellular component	0.84
transcription factor binding site profile	0.74
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.13   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.13   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (55)

Explore Interacting Targets

1 – 10 of 55

• See Interactions on String-DB

THY1

Tbio

Novelty:  0.00032846

p_int:  0.994592335

p_ni:  0.005407665

Data Source:  BioPlex

VNN2

Tbio

Novelty:  0.02286648

p_int:  0.991795562

p_ni:  0.008204438

Data Source:  BioPlex

RTP2

Tbio

Novelty:  0.05972678

p_int:  0.975305288

p_ni:  0.024694645

p_wrong:  6.7e-8

Data Source:  BioPlex

ART4

Tbio

Family:  Enzyme

Novelty:  0.15332159

p_int:  0.973068191

p_ni:  0.026931752

p_wrong:  5.6e-8

Data Source:  BioPlex

SPPL2B

Tchem

Family:  Enzyme

Novelty:  0.0274774

p_int:  0.932996511

p_ni:  0.067003476

p_wrong:  1.4e-8

Data Source:  BioPlex

PIGK

Tbio

Family:  Enzyme

Novelty:  0.02333499

p_int:  0.92103562

p_ni:  0.078964328

p_wrong:  5.3e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

NECTIN4

Tclin

Novelty:  0.00694563

p_int:  0.908659674

p_ni:  0.091340175

p_wrong:  1.51e-7

Score:  0.173

Data Source:  BioPlex,STRINGDB

LYPD3

Tbio

Novelty:  0.03248533

p_int:  0.893044361

p_ni:  0.106955639

p_wrong:  1e-9

Data Source:  BioPlex

PIGT

Tbio

Family:  Enzyme

Novelty:  0.02539879

p_int:  0.831194318

p_ni:  0.168805549

p_wrong:  1.34e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

CTLA4

Tclin

Novelty:  0.00012781

p_int:  0.830297788

p_ni:  0.169701873

p_wrong:  3.39e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (4)

KEGG (2)

UniProt (1)

Attachment of GPI anchor to uPAR (R-HSA-162791)

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Attachment of GPI anchor to uPAR	7 targets	R-HSA-162791
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Attachment of GPI anchor to uPAR	7 targets	R-HSA-162791
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (5)

Processes (3)

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Items per page:

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1 – 5 of 5

GO Term	Evidence	Assigned by
GPI-anchor transamidase complex	Inferred from Direct Assay (IDA)	UniProtKB
plasma membrane	Inferred from Direct Assay (IDA)	HGNC
membrane	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
endoplasmic reticulum membrane	Traceable Author Statement (TAS)	Reactome
integral component of endoplasmic reticulum membrane	Inferred by Curator (IC)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (24)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 24

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	3	6	10		98
glomerular filtration rate	EFO_0005208	4	4	4		95.6
melanoma	EFO_0000756	3	2	0	1.8	90.8
suntan	EFO_0004279	1	1	1		88.4
sex hormone-binding globulin measurement	EFO_0004696	4	2	4		87.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 24

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	10		98
glomerular filtration rate	EFO_0005208	4		95.6
melanoma	EFO_0000756	0	1.8	90.8
suntan	EFO_0004279	1		88.4
sex hormone-binding globulin measurement	EFO_0004696	4		87.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
GPI-anchor biosynthesis
Membrane
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
appendicular lean mass
BMI-adjusted hip circumference
C-reactive protein measurement
calcium measurement
coronary artery disease
creatinine measurement
feeling nervous measurement
glomerular filtration rate
hair color

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol glycan anchor biosynthesis class U	VGNC:6238	458193
Mouse	phosphatidylinositol glycan anchor biosynthesis, class U	MGI:3039607	228812
Rat	phosphatidylinositol glycan anchor biosynthesis, class U	RGD:727825	353304
Dog	phosphatidylinositol glycan anchor biosynthesis class U	VGNC:44543	485846
Horse	phosphatidylinositol glycan anchor biosynthesis class U	VGNC:21435	100054427

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol glycan anchor biosynthesis class U
Mouse	phosphatidylinositol glycan anchor biosynthesis, class U
Rat	phosphatidylinositol glycan anchor biosynthesis, class U
Dog	phosphatidylinositol glycan anchor biosynthesis class U
Horse	phosphatidylinositol glycan anchor biosynthesis class U

Publication Statistics

PubMed Score 8.13

PubMed score by year

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PubTator Score 3.14

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (4)

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0 of 0

PMID	Year	Title