Tbio FZD8 Frizzled-8

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-8

Protein / Receptor / G-protein Coupled Receptor / Frizzled-8

Protein / ... / Protease Inhibitor / Frizzled-8

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-8

Protein Summary

Description

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H461
• Fz-8

Gene Name

• FZD8

Ensembl ID

• ENST00000374694
• ENSP00000363826
• ENSG00000177283

Symbol

• FZ-8
• hFZ8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
biological process	0.88
transcription factor binding site profile	0.87
PubMedID	0.8
histone modification site profile	0.64

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.96   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 306   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.96   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 8	VGNC:3861	466040
Macaque	frizzled class receptor 8		708368
Mouse	frizzled class receptor 8	MGI:108460	14370
Opossum	frizzled class receptor 8 [Source:HGNC Symbol;Acc:HGNC:4046]
Anole lizard	frizzled class receptor 8		100561698

Species	Name	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 8
Macaque	frizzled class receptor 8
Mouse	frizzled class receptor 8
Opossum	frizzled class receptor 8 [Source:HGNC Symbol;Acc:HGNC:4046]
Anole lizard	frizzled class receptor 8

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H461-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (69)

Reactome (14)

KEGG (13)

PathwayCommons (30)

WikiPathways (12)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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Find Similar Targets

Items per page:

5

1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202

Gene Ontology Terms (18)

Functions (6)

Components (4)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
Wnt-activated receptor activity	Inferred from Direct Assay (IDA)	WormBase
PDZ domain binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
Wnt-protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
signaling receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (111)

Explore Interacting Targets

1 – 10 of 111

• See Interactions on String-DB

UPK1A

Tbio

Novelty: 0.01748122

p_int: 0.999753992

p_ni: 0.00020702

p_wrong: 0.000038988

Score: 0.181

Data Source: BioPlex,STRINGDB

IPPK

Tbio

Family: Enzyme

Novelty: 0.02169701

p_int: 0.983048326

p_ni: 0.015118316

p_wrong: 0.001833358

Score: 0.186

Data Source: BioPlex,STRINGDB

WNT3A

Tchem

Novelty: 0.00119275

Score: 0.991

Data Source: STRINGDB

LRP6

Tbio

Novelty: 0.00305615

Score: 0.985

Data Source: STRINGDB

LRP5

Tbio

Novelty: 0.00089807

Score: 0.982

Data Source: STRINGDB

WNT1

Tbio

Novelty: 0.00124301

Score: 0.981

Data Source: STRINGDB

WNT5A

Tbio

Novelty: 0.00125563

Score: 0.98

Data Source: STRINGDB

RYK

Tbio

Family: Kinase

Novelty: 0.00910227

Score: 0.979

Data Source: STRINGDB

WNT2B

Tbio

Novelty: 0.00783711

Score: 0.974

Data Source: STRINGDB

WNT2

Tbio

Novelty: 0.00313614

Score: 0.971

Data Source: STRINGDB

Publication Statistics

PubMed Score  53.96

PubMed score by year

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PubTator Score  34.07

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Cell membrane
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