Protein Summary
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. This intronless gene is a member of the frizzled gene ...more
- ENST00000374694
- ENSP00000363826
- ENSG00000177283
- FZ-8
- hFZ8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.94 | ||
biological process | 0.88 | ||
transcription factor binding site profile | 0.87 | ||
PubMedID | 0.8 | ||
histone modification site profile | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.05 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 306 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.05 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 306 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (111)
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (69)
Reactome (14)
KEGG (13)
PathwayCommons (30)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Class B/2 (Secretin family receptors) | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 8 | VGNC:3861 | 466040 | |||||
Macaque | frizzled class receptor 8 | 708368 | ||||||
Mouse | MGI:108460 | 14370 | ||||||
Opossum | frizzled class receptor 8 [Source:HGNC Symbol;Acc:HGNC:4046] | |||||||
Anole lizard | frizzled class receptor 8 | 100561698 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 8 | |||||
Macaque | frizzled class receptor 8 | |||||
Mouse | ||||||
Opossum | frizzled class receptor 8 [Source:HGNC Symbol;Acc:HGNC:4046] | |||||
Anole lizard | frizzled class receptor 8 | |||||
Publication Statistics
PubMed Score 57.05
PubMed score by year
PubTator Score 34.07
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (37)
GeneRif Annotations (16)
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