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Tbio
CHMP4B
Charged multivesicular body protein 4b

Protein Classes
Protein Summary
Description
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217402
  • ENSP00000217402
  • ENSG00000101421

Symbol
  • C20orf178
  • SHAX1
  • SNF7
  • CTPP3
  • Shax1
  • CHMP4A
  • SNF7-2
  • VPS32B
  • CTRCT31
  • Vps32-2
  • C20orf178
  • dJ553F4.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
biological process
0.91
interacting protein
0.9
virus perturbation
0.83
transcription factor binding site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.24   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.24   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
36.2
1
1
0
1.1
3.9
parental genotype effect measurement
1
1
1
2.4
birth weight
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
36.2
0
1.1
3.9
parental genotype effect measurement
1
2.4
birth weight
1
2.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 4B
VGNC:6080
747134
Macaque
charged multivesicular body protein 4B
709004
Mouse
MGI:1922858
75608
Rat
RGD:1583604
679886
Dog
charged multivesicular body protein 4B
VGNC:54643
485842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 4B
Macaque
charged multivesicular body protein 4B
Mouse
Rat
Dog
charged multivesicular body protein 4B
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H444-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Cellular responses to external stimuli
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Autophagy
Budding and maturation of HIV virion
Cellular responses to external stimuli
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (41)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (137)
1 – 10 of 137
CHMP2A
Tbio
Novelty: 0.00169253
Score: 0.999
Data Source: STRINGDB
CHMP3
Tbio
Novelty: 0.01958573
Score: 0.999
Data Source: STRINGDB
CHMP1B
Tbio
Novelty: 0.06982523
Score: 0.999
Data Source: STRINGDB
PDCD6IP
Tbio
Novelty: 0.01836118
Score: 0.995
Data Source: STRINGDB
VPS25
Tbio
Novelty: 0.03002488
Score: 0.994
Data Source: STRINGDB
VPS4A
Tbio
Novelty: 0.01508121
Score: 0.994
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00211746
Score: 0.992
Data Source: STRINGDB
VPS4B
Tbio
Novelty: 0.00788708
Score: 0.992
Data Source: STRINGDB
SNF8
Tbio
Novelty: 0.04841708
Score: 0.991
Data Source: STRINGDB
VPS36
Tbio
Novelty: 0.03382542
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.24

PubMed score by year
PubTator Score  22.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer