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Tchem
HIPK3
Homeodomain-interacting protein kinase 3

Protein Summary
Description
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303296
  • ENSP00000304226
  • ENSG00000110422
  • ENST00000379016
  • ENSP00000368301
  • ENST00000456517
  • ENSP00000398241
  • ENST00000525975
  • ENSP00000431710

Symbol
  • DYRK6
  • FIST3
  • PKY
  • PKY
  • YAK1
  • DYRK6
  • FIST3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.93
molecular function
0.9
small molecule
0.89
biological process
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.25   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.25   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (59)
1 – 10 of 59
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.908
Data Source: STRINGDB
DCAF7
Tbio
Novelty: 0.02609518
Score: 0.844
Data Source: STRINGDB
SRSF5
Tbio
Novelty: 0.01658346
Score: 0.834
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.824
Data Source: STRINGDB
RASSF5
Tbio
Novelty: 0.01035881
Score: 0.819
Data Source: STRINGDB
TRA2B
Tbio
Novelty: 0.0146833
Score: 0.788
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.774
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.721
Data Source: STRINGDB
VWA7
Tdark
Novelty: 0.15513587
Score: 0.66
Data Source: STRINGDB
KIAA1549L
Tdark
Novelty: 0.42483435
Score: 0.657
Data Source: STRINGDB
Publication Statistics
PubMed Score  129.25

PubMed score by year
PubTator Score  28.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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