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Tchem
HIPK3
Homeodomain-interacting protein kinase 3

Protein Summary
Description
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303296
  • ENSP00000304226
  • ENSG00000110422
  • ENST00000379016
  • ENSP00000368301
  • ENST00000456517
  • ENSP00000398241
  • ENST00000525975
  • ENSP00000431710

Symbol
  • DYRK6
  • FIST3
  • PKY
  • PKY
  • YAK1
  • DYRK6
  • FIST3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.93
molecular function
0.9
small molecule
0.89
biological process
0.85


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.64   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.64   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
AST-487
Rendered image for AST-487
silmitasertib
Rendered image for silmitasertib
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
1
3
46.5
cup-to-disc ratio measurement
2
1
2
33.1
alcohol use disorder measurement
1
1
1
31.4
sleep measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
46.5
cup-to-disc ratio measurement
2
33.1
alcohol use disorder measurement
1
31.4
sleep measurement
1
15.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeodomain interacting protein kinase 3
VGNC:1072
451109
Macaque
homeodomain interacting protein kinase 3
693786
Mouse
MGI:1314882
15259
Rat
RGD:619884
83617
Dog
homeodomain interacting protein kinase 3
VGNC:41695
475947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeodomain interacting protein kinase 3
Macaque
homeodomain interacting protein kinase 3
Mouse
Rat
Dog
homeodomain interacting protein kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H422-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (59)
1 – 10 of 59
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.908
Data Source:  STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
Score:  0.844
Data Source:  STRINGDB
SRSF5
Tbio
Novelty:  0.01658346
Score:  0.834
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.824
Data Source:  STRINGDB
RASSF5
Tbio
Novelty:  0.01035881
Score:  0.819
Data Source:  STRINGDB
TRA2B
Tbio
Novelty:  0.0146833
Score:  0.788
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.774
Data Source:  STRINGDB
SRSF1
Tbio
Novelty:  0.00074446
Score:  0.721
Data Source:  STRINGDB
VWA7
Tdark
Novelty:  0.15513587
Score:  0.66
Data Source:  STRINGDB
KIAA1549L
Tdark
Novelty:  0.42483435
Score:  0.657
Data Source:  STRINGDB
Publication Statistics
PubMed Score  132.64

PubMed score by year
PubTator Score  28.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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