Tbio DSN1 Kinetochore-associated protein DSN1 homolog

Protein Summary

Description

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9H410
• B4DWT2
• E1P5U9
• Q5JW55
• Q5JW56
• Q9H8P4

Gene Name

• DSN1

Ensembl ID

• ENST00000373734
• ENSP00000362839
• ENSG00000149636
• ENST00000373750
• ENSP00000362855
• ENST00000426836
• ENSP00000389810
• ENST00000448110
• ENSP00000404463

Symbol

• C20orf172
• MIS13
• KNL3
• MIS13
• hKNL-3
• C20orf172
• dJ469A13.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
transcription factor binding site profile	0.84
ligand (protein) perturbation	0.83
drug perturbation	0.71
hub protein	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.35   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.35   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0