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Tbio
DSN1
Kinetochore-associated protein DSN1 homolog

Protein Summary
Description
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373734
  • ENSP00000362839
  • ENSG00000149636
  • ENST00000373750
  • ENSP00000362855
  • ENST00000426836
  • ENSP00000389810
  • ENST00000448110
  • ENSP00000404463

Symbol
  • C20orf172
  • MIS13
  • KNL3
  • MIS13
  • hKNL-3
  • C20orf172
  • dJ469A13.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
drug perturbation
0.71
hub protein
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (244)
ZWINT
Tbio
Novelty:  0.02153276
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
NSL1
Tbio
Novelty:  0.01396984
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SPC25
Tbio
Novelty:  0.26354244
p_int:  1
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  1
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
SPC24
Tbio
Novelty:  0.03166479
p_int:  0.999999999
p_ni:  1e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
MIS12
Tbio
Novelty:  0.05345698
p_int:  0.999999698
p_ni:  3.02e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KNL1
Tbio
Novelty:  0.01084826
p_int:  0.999998866
p_ni:  0.000001134
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
NDC80
Tbio
Novelty:  0.00331814
p_int:  0.999993254
p_ni:  0.000006742
p_wrong:  4e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
NUF2
Tbio
Novelty:  0.01069726
p_int:  0.999985187
p_ni:  0.000014813
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.999757065
p_ni:  0.000242935
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
86.7
appendicular lean mass
3
2
3
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
86.7
appendicular lean mass
3
85.8
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DSN1 homolog, MIS12 kinetochore complex component
702251
Mouse
MGI:1914184
66934
Rat
RGD:1565179
499933
Dog
DSN1 homolog, MIS12 kinetochore complex component
VGNC:40109
610279
Cow
DSN1 homolog, MIS12 kinetochore complex component
VGNC:28224
508271
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DSN1 homolog, MIS12 kinetochore complex component
Mouse
Rat
Dog
DSN1 homolog, MIS12 kinetochore complex component
Cow
DSN1 homolog, MIS12 kinetochore complex component
Publication Statistics
PubMed Score 18.55
PubMed score by year
PubTator Score 5.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title