Tbio DNAJC5 DnaJ homolog subfamily C member 5

Protein Summary

Description

Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9H3Z4
• A8K0M0
• B3KY68
• E1P5G8
• Q9H3Z5
• Q9H7H2

Gene Name

• DNAJC5

Ensembl ID

• ENST00000360864
• ENSP00000354111
• ENSG00000101152
• ENST00000470551
• ENSP00000434744

Symbol

• CLN4
• CSP
• NCL
• CLN4
• CLN4B
• DNAJC5A
• mir-941-2
• mir-941-3
• mir-941-4
• mir-941-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
ligand (protein) perturbation	0.83
cellular component	0.8
transcription factor perturbation	0.8
tissue	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1199.16   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1199.16   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0