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Tbio
DNAJC5
DnaJ homolog subfamily C member 5

Protein Summary
Description
Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360864
  • ENSP00000354111
  • ENSG00000101152
  • ENST00000470551
  • ENSP00000434744

Symbol
  • CLN4
  • CSP
  • NCL
  • CLN4
  • CLN4B
  • DNAJC5A
  • mir-941-2
  • mir-941-3
  • mir-941-4
  • mir-941-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
ligand (protein) perturbation
0.83
cellular component
0.8
transcription factor perturbation
0.8
tissue
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 982.2   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 982.2   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
88
mean reticulocyte volume
1
1
1
79
alkaline phosphatase measurement
2
3
2
6.2
75.5
red blood cell density measurement
2
2
2
70.4
Agents acting on the renin-angiotensin system use measurement
1
1
1
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
88
mean reticulocyte volume
1
79
alkaline phosphatase measurement
2
6.2
75.5
red blood cell density measurement
2
70.4
Agents acting on the renin-angiotensin system use measurement
1
68
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C5
694810
Mouse
MGI:892995
13002
Rat
RGD:620516
79130
Dog
DnaJ heat shock protein family (Hsp40) member C5 [Source:HGNC Symbol;Acc:HGNC:16235]
Horse
DnaJ heat shock protein family (Hsp40) member C5
VGNC:51532
100051629
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C5
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C5 [Source:HGNC Symbol;Acc:HGNC:16235]
Horse
DnaJ heat shock protein family (Hsp40) member C5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H3Z4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
GABA synthesis, release, reuptake and degradation (R-HSA-888590)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA synthesis, release, reuptake and degradation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Name
Explore in Pharos
Explore in Source
GABA synthesis, release, reuptake and degradation
Immune System
Innate Immune System
Neuronal System
Neurotransmitter release cycle
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (234)
1 – 10 of 234
PTGFR
Tclin
Family:  GPCR
Novelty:  0.00560908
p_int:  0.998384324
p_ni:  0.000006229
p_wrong:  0.001609447
Score:  0.54
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.987
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.976
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.967
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.967
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.961
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.955
Data Source:  STRINGDB
DNAJC13
Tbio
Novelty:  0.03251995
Score:  0.95
Data Source:  STRINGDB
SNAP23
Tbio
Novelty:  0.0065371
Score:  0.947
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.928
Data Source:  STRINGDB
Publication Statistics
PubMed Score  982.20

PubMed score by year
PubTator Score  172.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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