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Tchem
SRMS
Tyrosine-protein kinase Srms

Protein Summary
Description
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217188
  • ENSP00000217188
  • ENSG00000125508

Symbol
  • C20orf148
  • SRM
  • PTK70
  • C20orf148
  • dJ697K14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
tissue
0.66
cell type or tissue
0.63
PubMedID
0.56


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dasatinib
Rendered image for dasatinib
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
70.5
electrocardiography
1
2
32
61.8
hair shape measurement
1
1
1
61
daytime rest measurement
1
1
1
55.2
mean reticulocyte volume
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
70.5
electrocardiography
32
61.8
hair shape measurement
1
61
daytime rest measurement
1
55.2
mean reticulocyte volume
1
31.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
470000
Mouse
MGI:101865
20811
Rat
RGD:1306602
296472
Dog
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
VGNC:46806
477286
Horse
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
VGNC:23585
100060563
Species
Name
OMA
EggNOG
Inparanoid
Chimp
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Mouse
Rat
Dog
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Horse
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H3Y6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (100)
PTK6 Down-Regulation (R-HSA-8849472)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 Down-Regulation
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 Down-Regulation
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (24)
1 – 10 of 24
PTK6
Tchem
Family:  Kinase
Novelty:  0.00480214
Score:  0.91
Data Source:  Reactome,STRINGDB
STK31
Tchem
Family:  Kinase
Novelty:  0.12405945
Score:  0.686
Data Source:  STRINGDB
TBRG4
Tbio
Novelty:  0.03556613
Score:  0.676
Data Source:  STRINGDB
DOK1
Tbio
Novelty:  0.01976327
Score:  0.596
Data Source:  STRINGDB
SNX8
Tbio
Novelty:  0.02652492
Score:  0.59
Data Source:  STRINGDB
KIFC3
Tbio
Novelty:  0.0662353
Score:  0.587
Data Source:  STRINGDB
SMCHD1
Tbio
Novelty:  0.01383021
Score:  0.552
Data Source:  STRINGDB
ZNF568
Tdark
Family:  TF
Novelty:  0.43535363
Score:  0.524
Data Source:  STRINGDB
GMEB2
Tdark
Family:  TF
Novelty:  0.1945427
Score:  0.523
Data Source:  STRINGDB
FAM102A
Tdark
Novelty:  0.32284443
Score:  0.519
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.15

PubMed score by year
PubTator Score  3.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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