Tbio TPK1 Thiamin pyrophosphokinase 1

Protein Summary

Description

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q9H3S4
• A8K0T7
• D3DWG0
• I6L9B8
• Q6NUR5
• Q9H602
• hTPK1

Gene Name

• TPK1

Ensembl ID

• ENST00000360057
• ENSP00000353165
• ENSG00000196511
• ENST00000645943
• ENSP00000494003
• ENSG00000285075

Symbol

• PP20
• HTPK1
• THMD5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
transcription factor binding site profile	0.85
transcription factor perturbation	0.8
gene perturbation	0.74
histone modification site profile	0.72

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Thiamine Pyrophosphokinase Family / Thiamin Pyrophosphokinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.58   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.58   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0