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Tbio
TPK1
Thiamin pyrophosphokinase 1

Protein Summary
Description
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360057
  • ENSP00000353165
  • ENSG00000196511
  • ENST00000645943
  • ENSP00000494003
  • ENSG00000285075

Symbol
  • PP20
  • HTPK1
  • THMD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor binding site profile
0.85
transcription factor perturbation
0.8
gene perturbation
0.74
histone modification site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.62   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.62   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
52
4
1
1
1.1
52
1
1
1
52
diet measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
52
1
1.1
52
1
52
diet measurement
1
14.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thiamin pyrophosphokinase 1
VGNC:4548
463818
Macaque
thiamin pyrophosphokinase 1
706237
Mouse
MGI:1352500
29807
Rat
RGD:1589408
680668
Dog
thiamin pyrophosphokinase 1
VGNC:47741
475515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thiamin pyrophosphokinase 1
Macaque
thiamin pyrophosphokinase 1
Mouse
Rat
Dog
thiamin pyrophosphokinase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H3S4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B1 (thiamin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B1 (thiamin) metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
DENND6A
Tbio
Novelty:  4.5572617
p_int:  0.99094282
p_ni:  0.00423727
p_wrong:  0.00481991
Data Source:  BioPlex
THTPA
Tbio
Family:  Enzyme
Novelty:  0.06922501
Score:  0.976
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.945
Data Source:  STRINGDB
AK1
Tbio
Family:  Kinase
Novelty:  0.00268549
Score:  0.94
Data Source:  STRINGDB
NTPCR
Tbio
Family:  Enzyme
Novelty:  0.0638186
Score:  0.921
Data Source:  STRINGDB
AK8
Tbio
Family:  Kinase
Novelty:  0.05983262
Score:  0.909
Data Source:  STRINGDB
AK5
Tbio
Family:  Kinase
Novelty:  0.01301579
Score:  0.906
Data Source:  STRINGDB
AK4
Tbio
Family:  Kinase
Novelty:  0.00977619
Score:  0.904
Data Source:  STRINGDB
AK2
Tbio
Family:  Kinase
Novelty:  0.00581034
Score:  0.904
Data Source:  STRINGDB
AK7
Tbio
Family:  Enzyme
Novelty:  0.0283556
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  89.62

PubMed score by year
PubTator Score  27.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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