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Tbio
SEMA4A
Semaphorin-4A

Protein Summary
Description
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and sup ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355014
  • ENSP00000347117
  • ENSG00000196189
  • ENST00000368282
  • ENSP00000357265
  • ENST00000368284
  • ENSP00000357267
  • ENST00000368285
  • ENSP00000357268

Symbol
  • SEMAB
  • SEMB
  • RP35
  • SEMB
  • SEMAB
  • CORD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.74
protein domain
0.73
transcription factor
0.71
disease perturbation
0.62
biological process
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
94.7
serum urea measurement
1
3
3
84.4
HbA1c measurement
2
2
2
82.4
body mass index
3
1
3
76.3
appendicular lean mass
3
2
4
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
94.7
serum urea measurement
3
84.4
HbA1c measurement
2
82.4
body mass index
3
76.3
appendicular lean mass
4
76.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 4A
VGNC:10993
457386
Macaque
semaphorin 4A
718191
Mouse
MGI:107560
20351
Rat
RGD:1304636
310630
Dog
semaphorin 4A
VGNC:45994
490416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 4A
Macaque
semaphorin 4A
Mouse
Rat
Dog
semaphorin 4A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H3S1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (137)
1 – 10 of 137
TMEM192
Tbio
Novelty:  0.30699087
p_int:  0.999339649
p_ni:  0.000660339
p_wrong:  1.2e-8
Data Source:  BioPlex
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.994464836
p_ni:  0.005535161
p_wrong:  3e-9
Data Source:  BioPlex
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.993990505
p_ni:  0.006008961
p_wrong:  5.34e-7
Data Source:  BioPlex
SIRT5
Tchem
Family:  Epigenetic
Novelty:  0.00225239
p_int:  0.993663319
p_ni:  0.006091591
p_wrong:  0.00024509
Data Source:  BioPlex
SEMA4B
Tbio
Novelty:  0.01387522
p_int:  0.993488178
p_ni:  0.006506451
p_wrong:  0.000005371
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.981875529
p_ni:  0.000913325
p_wrong:  0.017211146
Data Source:  BioPlex
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.994
Data Source:  Reactome,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.868
Data Source:  STRINGDB
PLXNB3
Tbio
Novelty:  0.02948198
Score:  0.861
Data Source:  STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
Score:  0.861
Data Source:  STRINGDB
Publication Statistics
PubMed Score  96.65

PubMed score by year
PubTator Score  36.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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