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Tbio
CENPH
Centromere protein H

Protein Summary
Description
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283006
  • ENSP00000283006
  • ENSG00000153044

Symbol
  • ICEN35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.68
cellular component
0.66
transcription factor binding site profile
0.59
tissue
0.52


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.26   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.26   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein H
VGNC:3945
742423
Macaque
centromere protein H
699620
Mouse
MGI:1349448
26886
Rat
RGD:1583506
681185
Dog
centromere protein H
VGNC:39104
610124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein H
Macaque
centromere protein H
Mouse
Rat
Dog
centromere protein H
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H3R5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (223)
1 – 10 of 223
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
p_int: 0.999999566
p_ni: 4.34e-7
Data Source: BioPlex
CCDC40
Tbio
Novelty: 0.06726469
p_int: 0.999998692
p_ni: 0.000001308
Score: 0.179
Data Source: BioPlex,STRINGDB
TEKT2
Tbio
Novelty: 0.04607893
p_int: 0.99996101
p_ni: 0.00003899
Score: 0.181
Data Source: BioPlex,STRINGDB
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.99930398
p_ni: 0.00069602
Data Source: BioPlex
CCDC151
Tbio
Novelty: 0.15952702
p_int: 0.994504561
p_ni: 0.005495397
p_wrong: 4.2e-8
Data Source: BioPlex
IFT57
Tbio
Novelty: 0.03373199
p_int: 0.994231101
p_ni: 0.005768898
p_wrong: 1e-9
Score: 0.245
Data Source: BioPlex,STRINGDB
CENPU
Tbio
Novelty: 0.03681625
p_int: 0.983564281
p_ni: 0.016435719
Score: 0.996
Data Source: BioPlex,STRINGDB
LMAN2
Tbio
Novelty: 0.02922729
p_int: 0.983559128
p_ni: 0.016440872
Score: 0.234
Data Source: BioPlex,STRINGDB
CCDC107
Tdark
Novelty: 1.10682722
p_int: 0.974117646
p_ni: 0.025882354
Data Source: BioPlex
SYCE3
Tdark
Novelty: 0.22361224
p_int: 0.971845915
p_ni: 0.028154085
Data Source: BioPlex
Publication Statistics
PubMed Score  37.26

PubMed score by year
PubTator Score  27.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer