Pharos : Target Details

Tbio

Protein Summary

Description

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]

Uniprot Accession IDs

Gene Name

MUC13

Ensembl ID

ENST00000616727
ENSP00000485028
ENSG00000173702

Symbol

DRCC1
RECC
DRCC1
MUC-13

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.72

cell type or tissue	0.7

protein domain	0.58

cell line	0.56

cellular component	0.52

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.68 (req: < 5)

View Publications

Gene RIFs: 21 (req: <= 3)

View Gene RIFs

Antibodies: 285 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.68 (req: >= 5)

Gene RIFs: 21 (req: > 3)

Antibodies: 285 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Protein-Protein Interactions (99)

1 – 10 of 99

See Interactions on String-DB

MUC17

Tbio

Novelty: 0.03624836

Score: 0.98

Data Source: STRINGDB

MUC20

Tbio

Novelty: 0.04645313

Score: 0.979

Data Source: STRINGDB

MUC12

Tbio

Novelty: 0.04323645

Score: 0.979

Data Source: STRINGDB

MUC4

Tbio

Novelty: 0.00193208

Score: 0.979

Data Source: STRINGDB

MUC15

Tbio

Novelty: 0.02213624

Score: 0.979

Data Source: STRINGDB

MUC3A

Tbio

Novelty: 0.0576775

Score: 0.974

Data Source: STRINGDB

GALNT14

Tchem

Family: Enzyme

Novelty: 0.04069117

Score: 0.972

Data Source: STRINGDB

MUC16

Tbio

Novelty: 0.00444587

Score: 0.972

Data Source: STRINGDB

MUC6

Tbio

Novelty: 0.00304872

Score: 0.971

Data Source: STRINGDB

MUC1

Tchem

Novelty: 0.00024203

Score: 0.969

Data Source: STRINGDB

Pathways (15)

Reactome (15)

C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481

Reactome	Dectin-2 family	29 targets	R-HSA-5621480

Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632

Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636

Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481

Dectin-2 family	29 targets	R-HSA-5621480

Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632

Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Gene Ontology Terms (10)

Functions (1)

Components (6)

Processes (3)

Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
visceral adipose tissue measurement	EFO_0004765	1	1	1		31.4

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
visceral adipose tissue measurement	EFO_0004765	1		31.4

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

No Header	No Header
Cell membrane

Complete proteome

Disulfide bond

EGF-like domain

Glycoprotein

Membrane

Polymorphism

Reference proteome

Repeat

Secreted

GWAS Trait

No Header	No Header
visceral adipose tissue measurement

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID
Mouse	mucin 13, epithelial transmembrane	MGI:103190	17063

Rat	mucin 13, cell surface associated	RGD:708547	207126

Dog	mucin 13, cell surface associated	VGNC:43498	478594

Cow	mucin 13, cell surface associated	VGNC:31758	100295610

Opossum	mucin 13, cell surface associated		100020197

Species	Name	OMA	EggNOG	Inparanoid
Mouse	mucin 13, epithelial transmembrane

Rat	mucin 13, cell surface associated

Dog	mucin 13, cell surface associated

Cow	mucin 13, cell surface associated

Opossum	mucin 13, cell surface associated

Publication Statistics

PubMed Score 82.68

PubMed score by year

PubTator Score 23.43

PubTator score by year