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Tbio
ACBD3
Golgi resident protein GCP60

Protein Summary
Description
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). (Microbial infection) Sensitizes PI4KB activation by Kobuviral (Aichi) 3A protein. The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366812
  • ENSP00000355777
  • ENSG00000182827

Symbol
  • GCP60
  • GOCAP1
  • GOLPH1
  • PAP7
  • GCP60
  • GOCAP1
  • GOLPH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor binding site profile
0.81
transcription factor perturbation
0.68
histone modification site profile
0.65
kinase perturbation
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.64   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.64   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA binding domain containing 3
VGNC:26
737563
Macaque
acyl-CoA binding domain containing 3
699311
Mouse
MGI:2181074
170760
Rat
RGD:727851
289312
Dog
acyl-CoA binding domain containing 3
VGNC:37500
611888
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA binding domain containing 3
Macaque
acyl-CoA binding domain containing 3
Mouse
Rat
Dog
acyl-CoA binding domain containing 3
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Protein-Protein Interactions (68)
1 – 10 of 68
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.997807442
p_ni: 0.002192557
Score: 0.189
Data Source: BioPlex,STRINGDB
TBC1D22A
Tbio
Novelty: 0.46374046
p_int: 0.943646996
p_ni: 0.056353004
Score: 0.851
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.807098183
p_ni: 0.192901817
Score: 0.495
Data Source: BioPlex,STRINGDB
GOLGB1
Tbio
Novelty: 0.00943584
Score: 0.981
Data Source: Reactome,STRINGDB
BLZF1
Tbio
Novelty: 0.04344183
Score: 0.901
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.818
Data Source: STRINGDB
PI4KB
Tchem
Family: Kinase
Novelty: 0.00856875
Score: 0.81
Data Source: STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
Score: 0.757
Data Source: STRINGDB
RTN1
Tbio
Novelty: 0.01828064
Score: 0.736
Data Source: STRINGDB
GOLGA3
Tbio
Novelty: 0.03018438
Score: 0.733
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.64

PubMed score by year
PubTator Score  23.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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