Tbio ACBD3 Golgi resident protein GCP60

Protein Summary

Description

Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). (Microbial infection) Sensitizes PI4KB activation by Kobuviral (Aichi) 3A protein. The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H3P7
• B2RB29
• Q5VTJ0
• Q6P9F1
• Q8IZC5
• Q8N4D6
• Q9H6U3

Gene Name

• ACBD3

Ensembl ID

• ENST00000366812
• ENSP00000355777
• ENSG00000182827

Symbol

• GCP60
• GOCAP1
• GOLPH1
• PAP7
• GCP60
• GOCAP1
• GOLPH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
transcription factor binding site profile	0.81
transcription factor perturbation	0.68
histone modification site profile	0.65
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.7   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 358   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.7   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0