You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NELFA
Negative elongation factor A

Protein Summary
Description
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner. Probably required to interact with the RNA polymerase II complex. This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syn ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000411638
  • ENSP00000399165
  • ENSG00000185049

Symbol
  • WHSC2
  • WHSC2
  • NELF-A
  • P/OKcl.15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
kinase perturbation
0.84
pathway
0.78
biological process
0.74
interacting protein
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
NELFE
Tbio
Novelty:  0.02136256
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NELFCD
Tbio
Novelty:  0.00094754
p_int:  0.999999984
p_ni:  1.3e-8
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NELFB
Tbio
Novelty:  0.05821821
p_int:  0.99999998
p_ni:  1.7e-8
p_wrong:  3e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.99996803
p_ni:  0.00003197
Score:  0.185
Data Source:  BioPlex,STRINGDB
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.999894738
p_ni:  0.000105257
p_wrong:  5e-9
Data Source:  BioPlex
MCM9
Tbio
Family:  Enzyme
Novelty:  0.0390791
p_int:  0.99798012
p_ni:  0.002012835
p_wrong:  0.000007045
Score:  0.187
Data Source:  BioPlex,STRINGDB
IGHMBP2
Tbio
Novelty:  0.01054517
p_int:  0.995990791
p_ni:  0.000009187
p_wrong:  0.004000021
Score:  0.757
Data Source:  BioPlex,STRINGDB
TMOD4
Tbio
Novelty:  0.00932697
p_int:  0.96144114
p_ni:  0.038514793
p_wrong:  0.000044068
Score:  0.187
Data Source:  BioPlex,STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.987
Data Source:  Reactome,STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
Score:  0.981
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
negative elongation factor complex member A
VGNC:645
461071
Macaque
negative elongation factor complex member A
712689
Mouse
MGI:1346098
24116
Rat
RGD:1305556
305455
Dog
negative elongation factor complex member A
VGNC:43736
488806
Species
Name
OMA
EggNOG
Inparanoid
Chimp
negative elongation factor complex member A
Macaque
negative elongation factor complex member A
Mouse
Rat
Dog
negative elongation factor complex member A
Publication Statistics
PubMed Score 11.18
PubMed score by year
PubTator Score 11.16
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title