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Tchem
HRH4
Histamine H4 receptor

Protein Summary
Description
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256906
  • ENSP00000256906
  • ENSG00000134489
  • ENST00000426880
  • ENSP00000402526

Symbol
  • GPCR105
  • H4
  • H4R
  • BG26
  • HH4R
  • AXOR35
  • GPRv53
  • GPCR105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.91
biological process
0.78
gene perturbation
0.78
tissue sample
0.74
biological term
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.46   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.46   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 516
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Pathways (12)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (241)
1 – 10 of 241
CCL16
Tbio
Novelty: 0.00156073
Score: 0.949
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
Score: 0.944
Data Source: STRINGDB
MCHR1
Tchem
Family: GPCR
Novelty: 0.00335291
Score: 0.926
Data Source: STRINGDB
SSTR4
Tclin
Family: GPCR
Novelty: 0.00416432
Score: 0.92
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00031121
Score: 0.919
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00039604
Score: 0.918
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.917
Data Source: STRINGDB
GRM6
Tchem
Family: GPCR
Novelty: 0.00909149
Score: 0.916
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.01077999
Score: 0.915
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0043523
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  276.46

PubMed score by year
PubTator Score  245.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer