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Tchem
HRH4
Histamine H4 receptor

Protein Summary
Description
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256906
  • ENSP00000256906
  • ENSG00000134489
  • ENST00000426880
  • ENSP00000402526

Symbol
  • GPCR105
  • H4
  • H4R
  • BG26
  • HH4R
  • AXOR35
  • GPRv53
  • GPCR105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.91
biological process
0.78
gene perturbation
0.78
tissue sample
0.74
biological term
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.06   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.06   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 558
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (241)
1 – 10 of 241
CCL16
Tbio
Novelty:  0.00489032
Score:  0.949
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.944
Data Source:  STRINGDB
MCHR1
Tchem
Family:  GPCR
Novelty:  0.00295097
Score:  0.926
Data Source:  STRINGDB
SSTR4
Tclin
Family:  GPCR
Novelty:  0.01528237
Score:  0.92
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.919
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.918
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.917
Data Source:  STRINGDB
GRM6
Tchem
Family:  GPCR
Novelty:  0.00681104
Score:  0.916
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.915
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.915
Data Source:  STRINGDB
Pathways (12)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
66.6
body height
1
1
1
33.1
diastolic blood pressure
1
1
0
5.4
0.6
self reported educational attainment
1
1
0
5.4
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
66.6
body height
1
33.1
diastolic blood pressure
0
5.4
0.6
self reported educational attainment
0
5.4
0.6
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H4
VGNC:5174
468501
Macaque
histamine receptor H4
702044
Mouse
MGI:2429635
225192
Rat
RGD:620631
170704
Dog
histamine receptor H4
VGNC:41788
490512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H4
Macaque
histamine receptor H4
Mouse
Rat
Dog
histamine receptor H4
Publication Statistics
PubMed Score 355.06
PubMed score by year
PubTator Score 245.89
PubTator score by year
Patents
Patents by year