TMX1
Thioredoxin-related transmembrane protein 1
Protein Summary
May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]
- ENST00000457354
- ENSP00000393316
- ENSG00000139921
- TMX
- TXNDC
- TXNDC1
- TMX
- TXNDC
- PDIA11
- TXNDC1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
transcription factor perturbation | 0.96 | ||
virus perturbation | 0.96 | ||
interacting protein | 0.94 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.49 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 252 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.49 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 252 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0