Tbio ATXN3L Ataxin-3-like protein

Protein Summary

Description

Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro). This intronless gene may be a pseudogene (PMID:11450850). This gene is similar to the multi-exon gene which encodes ataxin 3 and contains a coding region which could encode a protein similar to ataxin 3. Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q9H3M9
• B2RNY8

Gene Name

• ATXN3L

Ensembl ID

• ENST00000380622
• ENSP00000369996
• ENSG00000123594

Symbol

• ATX3L
• MJDL
• MJDL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
cell type or tissue	0.85
biological process	0.75
gene perturbation	0.68
tissue	0.47

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ataxin-3-like Protein

Protein / ... / Cysteine Protease / Ataxin-3-like Protein

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Ataxin-3-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0