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Tbio
GHITM
Growth hormone-inducible transmembrane protein

Protein Summary
Description
Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372134
  • ENSP00000361207
  • ENSG00000165678

Symbol
  • DERP2
  • MICS1
  • TMBIM5
  • DERP2
  • MICS1
  • My021
  • PTD010
  • TMBIM5
  • HSPC282
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.79
transcription factor perturbation
0.74
gene perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.64   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.64   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth hormone inducible transmembrane protein
VGNC:3866
450562
Macaque
growth hormone inducible transmembrane protein
702691
Mouse
MGI:1913342
66092
Rat
RGD:1359301
290596
Dog
growth hormone inducible transmembrane protein
VGNC:41205
479266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth hormone inducible transmembrane protein
Macaque
growth hormone inducible transmembrane protein
Mouse
Rat
Dog
growth hormone inducible transmembrane protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H3K2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (79)
1 – 10 of 79
SARM1
Tbio
Novelty: 0.00510488
p_int: 0.99999997
p_ni: 3e-8
Score: 0.212
Data Source: BioPlex,STRINGDB
C12orf73
Tdark
Novelty: 8.60557769
p_int: 0.999999683
p_wrong: 3.17e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
MFN2
Tbio
Novelty: 0.00137876
p_int: 0.999999666
p_ni: 3.34e-7
Score: 0.458
Data Source: BioPlex,STRINGDB
MTFR1L
Tdark
Novelty: 3.23781609
p_int: 0.999969125
p_ni: 0.000030874
Data Source: BioPlex
NT5C3A
Tbio
Family: Enzyme
Novelty: 0.01939545
p_int: 0.999944262
p_ni: 0.000055738
Data Source: BioPlex
POMK
Tbio
Family: Kinase
Novelty: 0.09340344
p_int: 0.999934942
p_ni: 0.000065058
Data Source: BioPlex
GK
Tbio
Family: Kinase
Novelty: 0.00617547
p_int: 0.999673331
p_ni: 0.000326669
Data Source: BioPlex
FNDC4
Tbio
Novelty: 0.31597146
p_int: 0.999274703
p_ni: 0.000725297
Data Source: BioPlex
SELENOH
Tbio
Novelty: 0.02421467
p_int: 0.998827349
p_ni: 0.001172639
p_wrong: 1.3e-8
Score: 0.168
Data Source: BioPlex,STRINGDB
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.997529292
p_ni: 0.002470708
Data Source: BioPlex
Publication Statistics
PubMed Score  297.64

PubMed score by year
PubTator Score  32.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer