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Tbio
C12orf65
Probable peptide chain release factor C12orf65, mitochondrial

Protein Summary
Description
May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion. May help rescuing stalled mitoribosomes during translation (By similarity). This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253233
  • ENSP00000253233
  • ENSG00000130921
  • ENST00000366329
  • ENSP00000390647
  • ENST00000429587
  • ENSP00000391513

Symbol
  • SPG55
  • COXPD7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
88.5
1
1
1
82.2
C-reactive protein measurement
1
1
1
78.3
mathematical ability
1
1
1
67.8
1
1
0
1.1
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
88.5
1
82.2
C-reactive protein measurement
1
78.3
mathematical ability
1
67.8
0
1.1
31.2
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (169)
1 – 10 of 169
MYLK2
Tchem
Family: Kinase
Novelty: 0.0080273
p_int: 0.865194938
p_ni: 0.134804531
p_wrong: 5.31e-7
Score: 0.689
Data Source: BioPlex,STRINGDB
MRPL58
Tbio
Family: Enzyme
Novelty: 0.00178011
Score: 0.939
Data Source: STRINGDB
MRPS16
Tbio
Novelty: 0.24108603
Score: 0.937
Data Source: STRINGDB
GFM1
Tbio
Novelty: 0.00503994
Score: 0.841
Data Source: STRINGDB
TSFM
Tbio
Novelty: 0.00468811
Score: 0.822
Data Source: STRINGDB
TUFM
Tbio
Novelty: 0.03251632
Score: 0.816
Data Source: STRINGDB
HOGA1
Tbio
Family: Enzyme
Novelty: 0.02409935
Score: 0.811
Data Source: STRINGDB
MTRF1L
Tbio
Family: Enzyme
Novelty: 0.08598685
Score: 0.801
Data Source: STRINGDB
MRPL17
Tdark
Novelty: 1.20541719
Score: 0.77
Data Source: STRINGDB
MRPS22
Tbio
Novelty: 0.06827343
Score: 0.751
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.74

PubMed score by year
PubTator Score  13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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