Protein Summary
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins ...more
- ENST00000264731
- ENSP00000264731
- ENSG00000073282
- ENST00000320472
- ENSP00000317510
- ENST00000354600
- ENSP00000346614
- ENST00000392460
- ENSP00000376253
- ENST00000392461
- ENSP00000376254
- ENST00000392463
- ENSP00000376256
- ENST00000418709
- ENSP00000407144
- ENST00000437221
- ENSP00000392488
- ENST00000440651
- ENSP00000394337
- ENST00000449992
- ENSP00000387839
- ENST00000456148
- ENSP00000389485
- KET
- P63
- P73H
- P73L
- TP73L
- AIS
- KET
- LMS
- NBP
- RHS
- p40
- p51
- p63
- EEC3
- OFC8
- p73H
- p73L
- SHFM4
- TP53L
- TP73L
- p53CP
- TP53CP
- B(p51A)
- B(p51B)
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
protein domain | 0.97 | ||
molecular function | 0.94 | ||
transcription factor perturbation | 0.94 | ||
trait | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 387.67 (req: < 5)
Gene RIFs: 832 (req: <= 3)
Antibodies: 794 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 387.67 (req: >= 5)
Gene RIFs: 832 (req: > 3)
Antibodies: 794 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 65
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0