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Tdark
UBQLN3
Ubiquilin-3

Protein Summary
Description
This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311659
  • ENSP00000347997
  • ENSG00000175520

Symbol
  • TUP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.65
tissue sample
0.64
tissue
0.45
cell line
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
3
83.3
sensory perception of smell
1
1
1
67.9
sodium measurement
1
2
2
63.6
1
1
0
2.2
59.9
mean corpuscular volume
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
83.3
sensory perception of smell
1
67.9
sodium measurement
2
63.6
0
2.2
59.9
mean corpuscular volume
1
58.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquilin 3
VGNC:12770
100610941
Macaque
ubiquilin 3
714488
Mouse
MGI:3045291
244178
Rat
RGD:1304920
308905
Dog
ubiquilin 3
VGNC:48086
476826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquilin 3
Macaque
ubiquilin 3
Mouse
Rat
Dog
ubiquilin 3
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H347-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (144)
1 – 10 of 144
UBA52
Tbio
Novelty:  0.01637744
Score:  0.775
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.748
Data Source:  STRINGDB
CCNA1
Tbio
Novelty:  0.0065671
Score:  0.737
Data Source:  STRINGDB
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
Score:  0.728
Data Source:  STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
Score:  0.715
Data Source:  STRINGDB
TMEM225
Tdark
Novelty:  0.54082299
Score:  0.686
Data Source:  STRINGDB
GTSF1L
Tdark
Novelty:  8.10289389
Score:  0.677
Data Source:  STRINGDB
DDI1
Tbio
Novelty:  0.02845222
Score:  0.672
Data Source:  STRINGDB
TMEM270
Tdark
Novelty:  1.34034992
Score:  0.668
Data Source:  STRINGDB
FAM71F1
Tdark
Novelty:  0.34155124
Score:  0.659
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.40

PubMed score by year
PubTator Score  15.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer