Protein Summary
This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016]
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.4 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 205 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.4 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 205 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (8)
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1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 3 | 3 | 3 | 83.3 | |||||
sensory perception of smell | 1 | 1 | 1 | 67.9 | |||||
sodium measurement | 1 | 2 | 2 | 63.6 | |||||
1 | 1 | 0 | 2.2 | 59.9 | |||||
mean corpuscular volume | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 3 | 83.3 | |||||
sensory perception of smell | 1 | 67.9 | |||||
sodium measurement | 2 | 63.6 | |||||
0 | 2.2 | 59.9 | |||||
mean corpuscular volume | 1 | 58.4 | |||||
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquilin 3 | VGNC:12770 | 100610941 | |||||
Macaque | ubiquilin 3 | 714488 | ||||||
Mouse | MGI:3045291 | 244178 | ||||||
Rat | RGD:1304920 | 308905 | ||||||
Dog | ubiquilin 3 | VGNC:48086 | 476826 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquilin 3 | |||||
Macaque | ubiquilin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquilin 3 | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (1)
KEGG (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Protein processing in endoplasmic reticulum | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Protein processing in endoplasmic reticulum | ||||
Protein-Protein Interactions (144)
1 – 10 of 144
UBA52
Novelty: 0.01637744
Score: 0.775
Data Source: STRINGDB
PSMD4
Family: Enzyme
Novelty: 0.00614538
Score: 0.748
Data Source: STRINGDB
CCNA1
Novelty: 0.0065671
Score: 0.737
Data Source: STRINGDB
LONRF2
Family: Enzyme
Novelty: 1.01811251
Score: 0.728
Data Source: STRINGDB
ADRM1
Novelty: 0.01545209
Score: 0.715
Data Source: STRINGDB
TMEM225
Novelty: 0.54082299
Score: 0.686
Data Source: STRINGDB
GTSF1L
Novelty: 8.10289389
Score: 0.677
Data Source: STRINGDB
DDI1
Novelty: 0.02845222
Score: 0.672
Data Source: STRINGDB
TMEM270
Novelty: 1.34034992
Score: 0.668
Data Source: STRINGDB
FAM71F1
Novelty: 0.34155124
Score: 0.659
Data Source: STRINGDB
Publication Statistics
PubMed Score 4.40
PubMed score by year
PubTator Score 15.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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