Protein Summary
This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.4 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 205 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.4 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 205 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (144)
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Protein processing in endoplasmic reticulum | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Protein processing in endoplasmic reticulum | ||||
Viral Interactions (0)
Gene Ontology Terms (0)
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 3 | 3 | 3 | 83.3 | |||||
sensory perception of smell | 1 | 1 | 1 | 67.9 | |||||
sodium measurement | 1 | 2 | 2 | 63.6 | |||||
1 | 1 | 0 | 2.2 | 59.9 | |||||
mean corpuscular volume | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 3 | 83.3 | |||||
sensory perception of smell | 1 | 67.9 | |||||
sodium measurement | 2 | 63.6 | |||||
0 | 2.2 | 59.9 | |||||
mean corpuscular volume | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquilin 3 | VGNC:12770 | 100610941 | |||||
Macaque | ubiquilin 3 | 714488 | ||||||
Mouse | MGI:3045291 | 244178 | ||||||
Rat | RGD:1304920 | 308905 | ||||||
Dog | ubiquilin 3 | VGNC:48086 | 476826 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquilin 3 | |||||
Macaque | ubiquilin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquilin 3 | |||||
Publication Statistics
PubMed Score 4.40
PubMed score by year
PubTator Score 15.47
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (2)
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0 of 0
PMID | Year | Title |
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