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Tbio
FOXP1
Forkhead box protein P1

Protein Summary
Description
Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-der ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318779
  • ENSP00000318721
  • ENSG00000114861
  • ENST00000318789
  • ENSP00000318902
  • ENST00000475937
  • ENSP00000419393
  • ENST00000484350
  • ENSP00000417857
  • ENST00000493089
  • ENSP00000418524
  • ENST00000498215
  • ENSP00000418102
  • ENST00000615603
  • ENSP00000484803
  • ENST00000622151
  • ENSP00000477918
  • ENST00000648107
  • ENSP00000497914
  • ENST00000648380
  • ENSP00000497344
  • ENST00000648426
  • ENSP00000498110
  • ENST00000648662
  • ENSP00000496873
  • ENST00000648718
  • ENSP00000496810
  • ENST00000649528
  • ENSP00000497369
  • ENST00000649631
  • ENSP00000496990
  • ENST00000649695
  • ENSP00000496841

Symbol
  • MFH
  • QRF1
  • 12CC4
  • hFKH1B
  • HSPC215
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
transcription factor perturbation
0.98
kinase perturbation
0.95
PubMedID
0.92
transcription factor
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.68   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.68   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
6
6
5.9
99.4
mathematical ability
3
2
3
97.3
smoking status measurement
2
2
4
96.9
lymphocyte count
3
3
5
92.1
2
2
0
1.1
91.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
5.9
99.4
mathematical ability
3
97.3
smoking status measurement
4
96.9
lymphocyte count
5
92.1
0
1.1
91.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box P1
VGNC:6266
736525
Macaque
forkhead box P1
694726
Mouse
MGI:1914004
108655
Rat
RGD:1308669
297480
Dog
forkhead box P1
VGNC:40965
484692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box P1
Macaque
forkhead box P1
Mouse
Rat
Dog
forkhead box P1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H334-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of pluripotent stem cells
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (127)
1 – 10 of 127
FOXP2
Tbio
Family: TF
Novelty: 0.00190504
p_int: 0.999999994
p_ni: 2e-9
p_wrong: 4e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00017205
p_int: 0.999999837
p_ni: 1.63e-7
p_wrong: 1e-9
Score: 0.867
Data Source: BioPlex,STRINGDB
CCDC183
Tdark
Novelty: 1.55719016
p_int: 0.999999403
p_ni: 5.97e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
NUP62CL
Tdark
Novelty: 2.93223607
p_int: 0.980625858
p_ni: 0.00568012
p_wrong: 0.013694022
Data Source: BioPlex
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.980016765
p_ni: 0.000526247
p_wrong: 0.019456988
Score: 0.171
Data Source: BioPlex,STRINGDB
LHX3
Tbio
Family: TF
Novelty: 0.00784158
Score: 0.749
Data Source: STRINGDB
IRX1
Tbio
Family: TF
Novelty: 0.01754936
Score: 0.71
Data Source: STRINGDB
SERPINA9
Tbio
Novelty: 0.04989426
Score: 0.707
Data Source: STRINGDB
CNTNAP2
Tbio
Novelty: 0.00238905
Score: 0.707
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.696
Data Source: STRINGDB
Publication Statistics
PubMed Score  325.68

PubMed score by year
PubTator Score  327.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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