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Tbio
FOXP1
Forkhead box protein P1

Protein Summary
Description
Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-der ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318779
  • ENSP00000318721
  • ENSG00000114861
  • ENST00000318789
  • ENSP00000318902
  • ENST00000475937
  • ENSP00000419393
  • ENST00000484350
  • ENSP00000417857
  • ENST00000493089
  • ENSP00000418524
  • ENST00000498215
  • ENSP00000418102
  • ENST00000615603
  • ENSP00000484803
  • ENST00000622151
  • ENSP00000477918
  • ENST00000648107
  • ENSP00000497914
  • ENST00000648380
  • ENSP00000497344
  • ENST00000648426
  • ENSP00000498110
  • ENST00000648662
  • ENSP00000496873
  • ENST00000648718
  • ENSP00000496810
  • ENST00000649528
  • ENSP00000497369
  • ENST00000649631
  • ENSP00000496990
  • ENST00000649695
  • ENSP00000496841

Symbol
  • MFH
  • QRF1
  • 12CC4
  • hFKH1B
  • HSPC215
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
transcription factor perturbation
0.98
kinase perturbation
0.95
PubMedID
0.92
transcription factor
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.63   (req: < 5)
Gene RIFs: 184   (req: <= 3)
Antibodies: 751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.63   (req: >= 5)
Gene RIFs: 184   (req: > 3)
Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0