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Tbio
FOXP1
Forkhead box protein P1

Protein Summary
Description
Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-der ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318779
  • ENSP00000318721
  • ENSG00000114861
  • ENST00000318789
  • ENSP00000318902
  • ENST00000475937
  • ENSP00000419393
  • ENST00000484350
  • ENSP00000417857
  • ENST00000493089
  • ENSP00000418524
  • ENST00000498215
  • ENSP00000418102
  • ENST00000615603
  • ENSP00000484803
  • ENST00000622151
  • ENSP00000477918
  • ENST00000648107
  • ENSP00000497914
  • ENST00000648380
  • ENSP00000497344
  • ENST00000648426
  • ENSP00000498110
  • ENST00000648662
  • ENSP00000496873
  • ENST00000648718
  • ENSP00000496810
  • ENST00000649528
  • ENSP00000497369
  • ENST00000649631
  • ENSP00000496990
  • ENST00000649695
  • ENSP00000496841

Symbol
  • MFH
  • QRF1
  • 12CC4
  • hFKH1B
  • HSPC215
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
transcription factor perturbation
0.98
kinase perturbation
0.95
PubMedID
0.92
transcription factor
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
FOXP2
Tbio
Family:  TF
Novelty:  0.00190504
p_int:  0.999999994
p_ni:  2e-9
p_wrong:  4e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
p_int:  0.999999837
p_ni:  1.63e-7
p_wrong:  1e-9
Score:  0.867
Data Source:  BioPlex,STRINGDB
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999999403
p_ni:  5.97e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.980625858
p_ni:  0.00568012
p_wrong:  0.013694022
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.980016765
p_ni:  0.000526247
p_wrong:  0.019456988
Score:  0.171
Data Source:  BioPlex,STRINGDB
LHX3
Tbio
Family:  TF
Novelty:  0.00784158
Score:  0.749
Data Source:  STRINGDB
IRX1
Tbio
Family:  TF
Novelty:  0.01754936
Score:  0.71
Data Source:  STRINGDB
SERPINA9
Tbio
Novelty:  0.04989426
Score:  0.707
Data Source:  STRINGDB
CNTNAP2
Tbio
Novelty:  0.00238905
Score:  0.707
Data Source:  STRINGDB
ISL1
Tbio
Family:  TF
Novelty:  0.00169431
Score:  0.696
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (69)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
5
96.9
self reported educational attainment
6
6
6
5.9
95.7
3
3
1
1.1
94.1
lymphocyte percentage of leukocytes
2
2
3
91.1
risk-taking behaviour
4
7
7
88.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
96.9
self reported educational attainment
6
5.9
95.7
1
1.1
94.1
lymphocyte percentage of leukocytes
3
91.1
risk-taking behaviour
7
88.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box P1
VGNC:6266
736525
Macaque
forkhead box P1
694726
Mouse
MGI:1914004
108655
Rat
RGD:1308669
297480
Dog
forkhead box P1
VGNC:40965
484692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box P1
Macaque
forkhead box P1
Mouse
Rat
Dog
forkhead box P1
Publication Statistics
PubMed Score 336.00
PubMed score by year
PubTator Score 327.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title