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Tbio
TTYH1
Protein tweety homolog 1

Protein Summary
Description
Probable chloride channel. May be involved in cell adhesion (By similarity). Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume. This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301194
  • ENSP00000301194
  • ENSG00000167614
  • ENST00000376530
  • ENSP00000365713
  • ENST00000376531
  • ENSP00000365714
  • ENST00000611133
  • ENSP00000480177
  • ENSG00000276887
  • ENST00000611471
  • ENSP00000484881
  • ENSG00000275650
  • ENST00000611711
  • ENSP00000484774
  • ENST00000614387
  • ENSP00000484077
  • ENST00000614458
  • ENSP00000484835
  • ENST00000616929
  • ENSP00000479779
  • ENSG00000276537
  • ENST00000619450
  • ENSP00000480769
  • ENST00000619453
  • ENSP00000484548
  • ENST00000619591
  • ENSP00000481601
  • ENST00000620133
  • ENSP00000483288
  • ENST00000620298
  • ENSP00000481138
  • ENST00000622771
  • ENSP00000482372
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cellular component
0.81
tissue sample
0.67
PubMedID
0.62
disease perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0