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Tbio
RHBG
Ammonium transporter Rh type B

Protein Summary
Description
Functions as a specific ammonium transporter. This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000537040
  • ENSP00000441197
  • ENSG00000132677

Symbol
  • SLC42A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
histone modification site profile
0.7
cellular component
0.62
molecular function
0.6
PubMedID
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.14   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.14   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.842
Data Source:  STRINGDB
SLC9A2
Tchem
Family:  Transporter
Novelty:  0.00687506
Score:  0.748
Data Source:  STRINGDB
SLC26A4
Tbio
Family:  Transporter
Novelty:  0.00162006
Score:  0.668
Data Source:  STRINGDB
SLC9A4
Tdark
Family:  Transporter
Novelty:  0.03346725
Score:  0.647
Data Source:  STRINGDB
TM4SF1
Tbio
Novelty:  0.02410436
Score:  0.627
Data Source:  STRINGDB
OCRL
Tbio
Family:  Enzyme
Novelty:  0.00555539
Score:  0.563
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.561
Data Source:  STRINGDB
TPD52L2
Tbio
Novelty:  0.03500169
Score:  0.544
Data Source:  STRINGDB
OSGEP
Tbio
Family:  Enzyme
Novelty:  0.0106198
Score:  0.536
Data Source:  STRINGDB
SLC12A1
Tclin
Family:  Transporter
Novelty:  0.00303604
Score:  0.522
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Rhesus glycoproteins mediate ammonium transport. (R-HSA-444411)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rhesus glycoproteins mediate ammonium transport.
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Rhesus glycoproteins mediate ammonium transport.
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
migraine disorder
4
3
0
1.1
97.5
HbA1c measurement
4
4
4
97.2
mean corpuscular hemoglobin concentration
3
3
3
92
TPE interval measurement
1
1
3
81.3
mean corpuscular volume
2
2
2
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
migraine disorder
0
1.1
97.5
HbA1c measurement
4
97.2
mean corpuscular hemoglobin concentration
3
92
TPE interval measurement
3
81.3
mean corpuscular volume
2
80.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rh family B glycoprotein
VGNC:10035
457394
Macaque
Rh family B glycoprotein
692069
Mouse
MGI:1927379
58176
Rat
RGD:727813
310625
Horse
Rh family B glycoprotein
100064158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rh family B glycoprotein
Macaque
Rh family B glycoprotein
Mouse
Rat
Horse
Rh family B glycoprotein
Publication Statistics
PubMed Score 65.14
PubMed score by year
PubTator Score 21.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title