Tbio PNN Pinin

Protein Summary

Description

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.

Uniprot Accession IDs

• Q9H307
• B4DZX8
• O60899
• Q53EM7
• Q6P5X4
• Q7KYL1
• Q99738
• Q9UHZ9
• Q9UQR9

Gene Name

• PNN

Ensembl ID

• ENST00000216832
• ENSP00000216832
• ENSG00000100941

Symbol

• DRS
• MEMA
• DRS
• DRSP
• SDK3
• memA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
interacting protein	0.98
transcription factor perturbation	0.88
disease perturbation	0.87
ligand (protein) perturbation	0.83

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.84   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 249   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.84   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pinin, desmosome associated protein	VGNC:7450	452875
Mouse	pinin	MGI:1100514	18949
Rat	pinin, desmosome associated protein	RGD:1597086	368070
Dog	pinin, desmosome associated protein	VGNC:44748	403907
Horse	pinin, desmosome associated protein	VGNC:21630	100060952

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pinin, desmosome associated protein
Mouse	pinin
Rat	pinin, desmosome associated protein
Dog	pinin, desmosome associated protein
Horse	pinin, desmosome associated protein

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9H307-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)

KEGG (2)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	mRNA surveillance pathway	88 targets	path:hsa03015
KEGG	RNA transport	157 targets	path:hsa03013

Name	Explore in Pharos	Explore in Source
mRNA surveillance pathway	88 targets	path:hsa03015
RNA transport	157 targets	path:hsa03013

Gene Ontology Terms (13)

Functions (3)

Components (8)

Processes (2)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural molecule activity	Non-traceable Author Statement (NAS)	ProtInc
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (146)

Explore Interacting Targets

1 – 10 of 146

• See Interactions on String-DB

EPB41L2

Tbio

Novelty: 0.0311733

p_int: 0.999991935

p_ni: 0.000008065

Score: 0.203

Data Source: BioPlex,STRINGDB

EPB41L1

Tbio

Novelty: 0.02937451

p_int: 0.999986255

p_ni: 0.000013745

Data Source: BioPlex

ZC3H14

Tbio

Novelty: 0.07532778

p_int: 0.999984909

p_ni: 0.000015091

Score: 0.558

Data Source: BioPlex,STRINGDB

CLK2

Tchem

Family: Kinase

Novelty: 0.13068449

p_int: 0.999982412

p_ni: 0.000017588

Score: 0.698

Data Source: BioPlex,STRINGDB

EPB41L3

Tbio

Novelty: 0.00915217

p_int: 0.999967918

p_ni: 0.000032082

Data Source: BioPlex

CAMKV

Tbio

Family: Kinase

Novelty: 0.17794181

p_int: 0.999927304

p_ni: 0.000072696

Data Source: BioPlex

AKAP17A

Tbio

Family: Enzyme

Novelty: 0.02860381

p_int: 0.999897846

p_ni: 0.000102154

Score: 0.356

Data Source: BioPlex,STRINGDB

NKAPD1

Tdark

Novelty: 1.56979675

p_int: 0.999897041

p_ni: 0.000102959

Score: 0.535

Data Source: BioPlex,STRINGDB

SAP18

Tbio

Family: Enzyme

Novelty: 0.03918373

p_int: 0.999893839

p_ni: 0.000106161

Score: 0.976

Data Source: BioPlex,STRINGDB

SNIP1

Tbio

Novelty: 0.01865867

p_int: 0.999889849

p_ni: 0.000110151

Score: 0.678

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  65.84

PubMed score by year

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PubTator Score  213.94

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Acetylation
Activator
Cell junction
Coiled coil
Complete proteome
Direct protein sequencing
DNA-binding
Isopeptide bond
Methylation
mRNA processing

MGI Phenotype Find Similar Targets

adipose tissue phenotype
cardiovascular system phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
skeleton phenotype