Protein Summary
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-c ...more
- ENST00000216832
- ENSP00000216832
- ENSG00000100941
- DRS
- MEMA
- DRS
- DRSP
- SDK3
- memA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
interacting protein | 0.98 | ||
transcription factor perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
ligand (protein) perturbation | 0.83 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.84 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 249 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.84 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 249 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pinin, desmosome associated protein | VGNC:7450 | 452875 | |||||
Mouse | MGI:1100514 | 18949 | ||||||
Rat | RGD:1597086 | 368070 | ||||||
Dog | pinin, desmosome associated protein | VGNC:44748 | 403907 | |||||
Horse | pinin, desmosome associated protein | VGNC:21630 | 100060952 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pinin, desmosome associated protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | pinin, desmosome associated protein | |||||
Horse | pinin, desmosome associated protein | |||||
Pathways (2)
KEGG (2)
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | mRNA surveillance pathway | ||||
KEGG | RNA transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
mRNA surveillance pathway | ||||
RNA transport | ||||
Gene Ontology Terms (13)
Functions (3)
Components (8)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (146)
1 – 10 of 146
EPB41L2
Novelty: 0.0311733
p_int: 0.999991935
p_ni: 0.000008065
Score: 0.203
Data Source: BioPlex,STRINGDB
EPB41L1
Novelty: 0.02937451
p_int: 0.999986255
p_ni: 0.000013745
Data Source: BioPlex
ZC3H14
Novelty: 0.07532778
p_int: 0.999984909
p_ni: 0.000015091
Score: 0.558
Data Source: BioPlex,STRINGDB
CLK2
Family: Kinase
Novelty: 0.13068449
p_int: 0.999982412
p_ni: 0.000017588
Score: 0.698
Data Source: BioPlex,STRINGDB
EPB41L3
Novelty: 0.00915217
p_int: 0.999967918
p_ni: 0.000032082
Data Source: BioPlex
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.999927304
p_ni: 0.000072696
Data Source: BioPlex
AKAP17A
Family: Enzyme
Novelty: 0.02860381
p_int: 0.999897846
p_ni: 0.000102154
Score: 0.356
Data Source: BioPlex,STRINGDB
NKAPD1
Novelty: 1.56979675
p_int: 0.999897041
p_ni: 0.000102959
Score: 0.535
Data Source: BioPlex,STRINGDB
SAP18
Family: Enzyme
Novelty: 0.03918373
p_int: 0.999893839
p_ni: 0.000106161
Score: 0.976
Data Source: BioPlex,STRINGDB
SNIP1
Novelty: 0.01865867
p_int: 0.999889849
p_ni: 0.000110151
Score: 0.678
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 65.84
PubMed score by year
PubTator Score 213.94
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword