Tbio PNN Pinin

Protein Summary

Description

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.

Uniprot Accession IDs

• Q9H307
• B4DZX8
• O60899
• Q53EM7
• Q6P5X4
• Q7KYL1
• Q99738
• Q9UHZ9
• Q9UQR9

Gene Name

• PNN

Ensembl ID

• ENST00000216832
• ENSP00000216832
• ENSG00000100941

Symbol

• DRS
• MEMA
• DRS
• DRSP
• SDK3
• memA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
interacting protein	0.98
transcription factor perturbation	0.88
disease perturbation	0.87
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.24   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 249   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.24   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (146)

Explore Interacting Targets

1 – 10 of 146

• See Interactions on String-DB

EPB41L2

Tbio

Novelty:  0.0311733

p_int:  0.999991935

p_ni:  0.000008065

Score:  0.203

Data Source:  BioPlex,STRINGDB

EPB41L1

Tbio

Novelty:  0.02937451

p_int:  0.999986255

p_ni:  0.000013745

Data Source:  BioPlex

ZC3H14

Tbio

Novelty:  0.07532778

p_int:  0.999984909

p_ni:  0.000015091

Score:  0.558

Data Source:  BioPlex,STRINGDB

CLK2

Tchem

Family:  Kinase

Novelty:  0.13068449

p_int:  0.999982412

p_ni:  0.000017588

Score:  0.698

Data Source:  BioPlex,STRINGDB

EPB41L3

Tbio

Novelty:  0.00915217

p_int:  0.999967918

p_ni:  0.000032082

Data Source:  BioPlex

CAMKV

Tbio

Family:  Kinase

Novelty:  0.17794181

p_int:  0.999927304

p_ni:  0.000072696

Data Source:  BioPlex

AKAP17A

Tbio

Family:  Enzyme

Novelty:  0.02860381

p_int:  0.999897846

p_ni:  0.000102154

Score:  0.356

Data Source:  BioPlex,STRINGDB

NKAPD1

Tdark

Novelty:  1.56979675

p_int:  0.999897041

p_ni:  0.000102959

Score:  0.535

Data Source:  BioPlex,STRINGDB

SAP18

Tbio

Family:  Enzyme

Novelty:  0.03918373

p_int:  0.999893839

p_ni:  0.000106161

Score:  0.976

Data Source:  BioPlex,STRINGDB

SNIP1

Tbio

Novelty:  0.01865867

p_int:  0.999889849

p_ni:  0.000110151

Score:  0.678

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (2)

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	mRNA surveillance pathway	88 targets	path:hsa03015
KEGG	RNA transport	157 targets	path:hsa03013

Name	Explore in Pharos	Explore in Source
mRNA surveillance pathway	88 targets	path:hsa03015
RNA transport	157 targets	path:hsa03013

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (3)

Components (8)

Processes (2)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural molecule activity	Non-traceable Author Statement (NAS)	ProtInc
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	8	4	8		96.8
self reported educational attainment	EFO_0004784	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	8		96.8
self reported educational attainment	EFO_0004784	1		35

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Activator
Cell junction
Coiled coil
Complete proteome
Direct protein sequencing
DNA-binding
Isopeptide bond
Methylation
mRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
self reported educational attainment
vitamin D measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
cardiovascular system phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pinin, desmosome associated protein	VGNC:7450	452875
Mouse	pinin	MGI:1100514	18949
Rat	pinin, desmosome associated protein	RGD:1597086	368070
Dog	pinin, desmosome associated protein	VGNC:44748	403907
Horse	pinin, desmosome associated protein	VGNC:21630	100060952

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pinin, desmosome associated protein
Mouse	pinin
Rat	pinin, desmosome associated protein
Dog	pinin, desmosome associated protein
Horse	pinin, desmosome associated protein

Publication Statistics

PubMed Score 68.24

PubMed score by year

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PubTator Score 213.94

PubTator score by year

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Related Publications

Text Mined References (49)

GeneRif Annotations (15)

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10

0 of 0

PMID	Year	Title