You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PARL
Presenilins-associated rhomboid-like protein, mitochondrial

Protein Summary
Description
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311101
  • ENSP00000310676
  • ENSG00000175193
  • ENST00000317096
  • ENSP00000325421

Symbol
  • PSARL
  • PSARL
  • PSARL1
  • RHBDS1
  • PRO2207
  • PSENIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
disease perturbation
0.96
histone modification site profile
0.72
transcription factor binding site profile
0.71
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.7   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.7   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
EEF2KMT
Tdark
Family:  Enzyme
Novelty:  0.33892681
p_int:  0.999948384
p_ni:  0.000043512
p_wrong:  0.000008104
Score:  0.209
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.996259819
p_ni:  0.001696488
p_wrong:  0.002043693
Score:  0.156
Data Source:  BioPlex,STRINGDB
CHST10
Tbio
Family:  Enzyme
Novelty:  0.06829376
p_int:  0.973475225
p_ni:  0.026523839
p_wrong:  9.36e-7
Score:  0.203
Data Source:  BioPlex,STRINGDB
ENAH
Tbio
Novelty:  0.02329247
p_int:  0.960538817
p_ni:  0.039461183
Score:  0.209
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.947018032
p_ni:  0.052603443
p_wrong:  0.000378525
Data Source:  BioPlex
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.872771149
p_ni:  0.127022142
p_wrong:  0.00020671
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.863498855
p_ni:  0.136497422
p_wrong:  0.000003723
Data Source:  BioPlex
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.861527882
p_ni:  0.138470806
p_wrong:  0.000001312
Score:  0.157
Data Source:  BioPlex,STRINGDB
HIST2H2AB
Tbio
Novelty:  0.06772132
p_int:  0.84033719
p_ni:  0.159662762
p_wrong:  4.7e-8
Score:  0.157
Data Source:  BioPlex,STRINGDB
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.751624064
p_ni:  0.248362238
p_wrong:  0.000013698
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
70.2
platelet count
1
1
1
53.3
red blood cell distribution width
2
1
2
52
body height
1
1
1
42.3
C-reactive protein measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
70.2
platelet count
1
53.3
red blood cell distribution width
2
52
body height
1
42.3
C-reactive protein measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
presenilin associated rhomboid like
VGNC:9696
460877
Macaque
presenilin associated rhomboid like
704652
Mouse
MGI:1277152
381038
Rat
RGD:1306191
287979
Dog
presenilin associated rhomboid like
VGNC:54107
488100
Species
Name
OMA
EggNOG
Inparanoid
Chimp
presenilin associated rhomboid like
Macaque
presenilin associated rhomboid like
Mouse
Rat
Dog
presenilin associated rhomboid like
Publication Statistics
PubMed Score 77.70
PubMed score by year
PubTator Score 46.87
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title