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Tdark
NKX2-4
Homeobox protein Nkx-2.4

Protein Summary
Description
Probable transcription factor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351817
  • ENSP00000345147
  • ENSG00000125816

Symbol
  • NKX2D
  • NKX2D
  • NKX2.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.62
protein domain
0.58
PubMedID
0.58
cell type or tissue
0.53
cell line
0.4


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 4
VGNC:6215
469893
Macaque
NK2 homeobox 4
705258
Mouse
MGI:97349
228731
Rat
Cow
NK2 homeobox 4
VGNC:32101
787396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 4
Macaque
NK2 homeobox 4
Mouse
Rat
Cow
NK2 homeobox 4
Protein-Protein Interactions (21)
1 – 10 of 21
DCUN1D1
Tbio
Novelty: 0.03122408
Score: 0.904
Data Source: STRINGDB
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.515
Data Source: STRINGDB
TBX4
Tbio
Family: TF
Novelty: 0.01370005
Score: 0.509
Data Source: STRINGDB
ZNF202
Tbio
Family: TF
Novelty: 0.06306212
Score: 0.502
Data Source: STRINGDB
LHX6
Tbio
Family: TF
Novelty: 0.01603143
Score: 0.495
Data Source: STRINGDB
FOXB2
Tdark
Family: TF
Novelty: 0.40241439
Score: 0.481
Data Source: STRINGDB
TBX5
Tbio
Family: TF
Novelty: 0.00272208
Score: 0.47
Data Source: STRINGDB
EVA1B
Tdark
Novelty: 2.1380272
Score: 0.441
Data Source: STRINGDB
GSX2
Tbio
Family: TF
Novelty: 0.01688324
Score: 0.435
Data Source: STRINGDB
STK31
Tchem
Family: Kinase
Novelty: 0.12405945
Score: 0.42
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.57

PubMed score by year
PubTator Score  0.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer