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Tchem
SLC12A5
Solute carrier family 12 member 5

Protein Summary
Description
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript v ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243964
  • ENSP00000243964
  • ENSG00000124140
  • ENST00000454036
  • ENSP00000387694

Symbol
  • KCC2
  • KIAA1176
  • KCC2
  • EIG14
  • hKCC2
  • EIEE34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.7
small molecule perturbation
0.62
gene perturbation
0.6
molecular function
0.6
microRNA
0.59


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 659.58   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 659.58   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
VU0240551
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1
90
neuroticism measurement
1
1
1
72.9
depressive symptom measurement
1
1
1
72.9
mathematical ability
1
1
1
68.5
wellbeing measurement
1
1
1
39
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
90
neuroticism measurement
1
72.9
depressive symptom measurement
1
72.9
mathematical ability
1
68.5
wellbeing measurement
1
39
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 5
VGNC:9979
458295
Macaque
solute carrier family 12 member 5
707974
Mouse
MGI:1862037
57138
Rat
RGD:620811
171373
Dog
solute carrier family 12 member 5
VGNC:46222
485905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 5
Macaque
solute carrier family 12 member 5
Mouse
Rat
Dog
solute carrier family 12 member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2X9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cation-coupled Chloride cotransporters (R-HSA-426117)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cation-coupled Chloride cotransporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cation-coupled Chloride cotransporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (138)
1 – 10 of 138
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999503163
p_ni: 0.000434072
p_wrong: 0.000062765
Score: 0.179
Data Source: BioPlex,STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999503163
p_ni: 0.000434072
p_wrong: 0.000062765
Score: 0.157
Data Source: BioPlex,STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.852
Data Source: STRINGDB
STK39
Tbio
Family: Kinase
Novelty: 0.00548476
Score: 0.826
Data Source: STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.797
Data Source: STRINGDB
WNK1
Tchem
Family: Kinase
Novelty: 0.00270535
Score: 0.789
Data Source: STRINGDB
WNK3
Tchem
Family: Kinase
Novelty: 0.03382701
Score: 0.783
Data Source: STRINGDB
GABRR3
Tbio
Family: IC
Novelty: 0.01890426
Score: 0.762
Data Source: STRINGDB
SLC32A1
Tchem
Family: Transporter
Novelty: 0.00237273
Score: 0.745
Data Source: STRINGDB
GLRB
Tclin
Family: IC
Novelty: 0.01721113
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  659.58

PubMed score by year
PubTator Score  201.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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