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Tdark
IFI27L2
Interferon alpha-inducible protein 27-like protein 2

Protein Summary
Description
Plays a role in the apoptotic process and has a pro-apoptotic activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238609
  • ENSP00000238609
  • ENSG00000119632
  • ENST00000619362
  • ENSP00000482521
  • ENSG00000276879

Symbol
  • FAM14A
  • TLH29
  • TLH29
  • FAM14A
  • ISG12B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
histone modification site profile
0.75
tissue sample
0.63
cellular component
0.48
cell line
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
1
1
36.9
serum albumin measurement
1
1
1
36.9
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
36.9
serum albumin measurement
1
36.9
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon alpha inducible protein 27 like 2
VGNC:12805
741497
Mouse
MGI:1924183
76933
Rat
RGD:1559721
299269
Horse
interferon alpha-inducible protein 27-like protein 2
100064891
Cow
interferon, alpha-inducible protein 27-like 2
535465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon alpha inducible protein 27 like 2
Mouse
Rat
Horse
interferon alpha-inducible protein 27-like protein 2
Cow
interferon, alpha-inducible protein 27-like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2X8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (263)
Items per page:
1 – 5 of 263
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Non-genomic actions of 1,25 dihydroxyvitamin D3
WikiPathways
Non-genomic actions of 1,25 dihydroxyvitamin D3
WikiPathways
Non-genomic actions of 1,25 dihydroxyvitamin D3
WikiPathways
Non-genomic actions of 1,25 dihydroxyvitamin D3
WikiPathways
Non-genomic actions of 1,25 dihydroxyvitamin D3
Name
Explore in Pharos
Explore in Source
Non-genomic actions of 1,25 dihydroxyvitamin D3
Non-genomic actions of 1,25 dihydroxyvitamin D3
Non-genomic actions of 1,25 dihydroxyvitamin D3
Non-genomic actions of 1,25 dihydroxyvitamin D3
Non-genomic actions of 1,25 dihydroxyvitamin D3
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (12)
1 – 10 of 12
TMEM168
Tdark
Novelty:  0.89372034
Score:  0.565
Data Source:  STRINGDB
OLFML1
Tdark
Novelty:  0.27791923
Score:  0.516
Data Source:  STRINGDB
UBE2L6
Tbio
Novelty:  0.03471633
Score:  0.498
Data Source:  STRINGDB
CMPK2
Tbio
Family:  Kinase
Novelty:  0.01285082
Score:  0.496
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.458
Data Source:  STRINGDB
USP18
Tbio
Family:  Enzyme
Novelty:  0.01087689
Score:  0.441
Data Source:  STRINGDB
STC2
Tbio
Novelty:  0.00965684
Score:  0.427
Data Source:  STRINGDB
ITLN2
Tbio
Novelty:  0.15601654
Score:  0.425
Data Source:  STRINGDB
DNAJC5B
Tdark
Novelty:  0.28962584
Score:  0.42
Data Source:  STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
Score:  0.416
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.75

PubMed score by year
PubTator Score  0.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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