Tbio CLEC4M C-type lectin domain family 4 member M

Protein Summary

Description

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. (Microbial infection) Acts as an attachment receptor for HIV-1. (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. (Microbial infection) Acts as an attachment receptor for Influenzavirus. (Microbial infection) Acts as an attachment receptor for SARS coronavirus. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9H2X3
• A6NKI4
• A8K8B3
• Q69F40
• Q969M4
• Q96QP3
• Q96QP4
• Q96QP5
• Q96QP6
• Q9BXS3
• Q9H2Q9
• Q9H8F0
• Q9Y2A8

Gene Name

• CLEC4M

Ensembl ID

• ENST00000248228
• ENSP00000248228
• ENSG00000104938
• ENST00000327325
• ENSP00000316228
• ENST00000359059
• ENSP00000351954
• ENST00000595496
• ENSP00000470132
• ENST00000596363
• ENSP00000471125
• ENST00000597522
• ENSP00000471132

Symbol

• CD209L
• CD209L1
• CD299
• CD299
• LSIGN
• CD209L
• L-SIGN
• DCSIGNR
• HP10347
• DC-SIGN2
• DC-SIGNR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
cell type or tissue	0.7
biological term	0.69
microRNA	0.63
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member M

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member M

Protein / Cell Adhesion Molecule / C-type Lectin Domain Family 4 Member M

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member M

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.24   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 397   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.24   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0