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Tbio
CLEC4M
C-type lectin domain family 4 member M

Protein Summary
Description
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. (Microbial infection) Acts as an attachment receptor for HIV-1. (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. (Microbial infection) Acts as an attachment receptor for Influenzavirus. (Microbial infection) Acts as an attachment receptor for SARS coronavirus. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment rece ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248228
  • ENSP00000248228
  • ENSG00000104938
  • ENST00000327325
  • ENSP00000316228
  • ENST00000359059
  • ENSP00000351954
  • ENST00000595496
  • ENSP00000470132
  • ENST00000596363
  • ENSP00000471125
  • ENST00000597522
  • ENSP00000471132

Symbol
  • CD209L
  • CD209L1
  • CD299
  • CD299
  • LSIGN
  • CD209L
  • L-SIGN
  • DCSIGNR
  • HP10347
  • DC-SIGN2
  • DC-SIGNR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
cell type or tissue
0.7
biological term
0.69
microRNA
0.63
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.24   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.24   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0