You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MIXL1
Homeobox protein MIXL1

Protein Summary
Description
Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366810
  • ENSP00000355775
  • ENSG00000185155
  • ENST00000542034
  • ENSP00000442439

Symbol
  • MIXL
  • MIX
  • MIXL
  • MILD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.75
histone modification site profile
0.66
disease
0.56
cellular component
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 605.17   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 605.17   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Endoderm Differentiation
WikiPathways
PDGFR-beta pathway
Name
Explore in Pharos
Explore in Source
Adipogenesis
Adipogenesis
Mesodermal Commitment Pathway
Endoderm Differentiation
PDGFR-beta pathway
Gene Ontology Terms (23)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (56)
1 – 10 of 56
FOXH1
Tbio
Family: TF
Novelty: 0.00589427
Score: 0.835
Data Source: STRINGDB
TBXT
Tbio
Family: TF
Novelty: 0.00479096
Score: 0.806
Data Source: STRINGDB
EOMES
Tbio
Family: TF
Novelty: 0.00407653
Score: 0.783
Data Source: STRINGDB
SOX17
Tbio
Family: TF
Novelty: 0.00474245
Score: 0.769
Data Source: STRINGDB
FOXA2
Tbio
Family: TF
Novelty: 0.00339972
Score: 0.73
Data Source: STRINGDB
TBX6
Tbio
Family: TF
Novelty: 0.01366159
Score: 0.682
Data Source: STRINGDB
FOXA1
Tbio
Family: TF
Novelty: 0.00323694
Score: 0.68
Data Source: STRINGDB
SOX1
Tbio
Family: TF
Novelty: 0.00791998
Score: 0.664
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00115226
Score: 0.663
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00073323
Score: 0.655
Data Source: STRINGDB
Publication Statistics
PubMed Score  605.17

PubMed score by year
PubTator Score  211.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer