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Tbio
ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

Protein Summary
Description
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity). This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000175238
  • ENSP00000175238
  • ENSG00000069206
  • ENST00000441335
  • ENSP00000393073

Symbol
  • GP83
  • EAPI
  • GP83
  • GP-83
  • ADAM 7
  • ADAM-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.76
cell line
0.53
molecular function
0.49
co-expressed gene
0.48


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.52   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.52   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (21)
1 – 10 of 21
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.997344677
p_ni:  0.002655323
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.974414425
p_ni:  0.025585575
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.810974836
p_ni:  0.189025164
Data Source:  BioPlex
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
p_int:  0.78554336
p_ni:  0.21445664
Data Source:  BioPlex
ZNF146
Tbio
Family:  TF
Novelty:  0.05977172
p_int:  0.766518118
p_ni:  0.232721795
p_wrong:  0.000760088
Data Source:  BioPlex
IMPG1
Tbio
Novelty:  0.03770903
Score:  0.651
Data Source:  STRINGDB
CPED1
Tdark
Family:  Enzyme
Novelty:  0.13549237
Score:  0.648
Data Source:  STRINGDB
CPNE8
Tbio
Novelty:  0.14023162
Score:  0.613
Data Source:  STRINGDB
JPH3
Tbio
Novelty:  0.01661507
Score:  0.592
Data Source:  STRINGDB
LCN8
Tbio
Novelty:  0.02098116
Score:  0.583
Data Source:  STRINGDB
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 7
VGNC:927
464062
Macaque
ADAM metallopeptidase domain 7
100427614
Mouse
MGI:107247
11500
Rat
RGD:62032
29641
Dog
ADAM metallopeptidase domain 7
VGNC:37586
477379
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 7
Macaque
ADAM metallopeptidase domain 7
Mouse
Rat
Dog
ADAM metallopeptidase domain 7
Publication Statistics
PubMed Score 48.52
PubMed score by year
PubTator Score 19.34
PubTator score by year