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Tbio
DHX36
ATP-dependent DNA/RNA helicase DHX36

Protein Summary
Description
Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308361
  • ENSP00000309296
  • ENSG00000174953
  • ENST00000329463
  • ENSP00000330113
  • ENST00000496811
  • ENSP00000417078

Symbol
  • DDX36
  • KIAA1488
  • MLEL1
  • RHAU
  • G4R1
  • RHAU
  • DDX36
  • MLEL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
virus perturbation
0.88
kinase perturbation
0.84
cell type or tissue
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.91   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.91   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.960890599
p_ni:  0.039109401
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.93950705
p_ni:  0.06049295
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.938720487
p_ni:  0.061279513
Data Source:  BioPlex
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.934577705
p_ni:  0.065422293
p_wrong:  2e-9
Data Source:  BioPlex
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.934142012
p_ni:  0.065857988
Data Source:  BioPlex
BYSL
Tbio
Novelty:  0.01919968
p_int:  0.914525657
p_ni:  0.085474342
Score:  0.469
Data Source:  BioPlex,STRINGDB
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.882750118
p_ni:  0.117249882
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.835318692
p_ni:  0.164681308
Data Source:  BioPlex
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.834691454
p_ni:  0.165308546
Data Source:  BioPlex
ZBTB38
Tbio
Family:  TF
Novelty:  0.05048192
p_int:  0.784599466
p_ni:  0.215400534
Score:  0.201
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (63)
Find Similar Targets
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
86.3
2
2
2
75.7
apolipoprotein A 1 measurement
1
1
1
53.3
comparative body size at age 10, self-reported
1
1
1
52
high density lipoprotein cholesterol measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
86.3
2
75.7
apolipoprotein A 1 measurement
1
53.3
comparative body size at age 10, self-reported
1
52
high density lipoprotein cholesterol measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 36
VGNC:7057
460791
Macaque
DEAH-box helicase 36
708112
Mouse
MGI:1919412
72162
Rat
RGD:1308767
310461
Dog
DEAH-box helicase 36
VGNC:39946
477117
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 36
Macaque
DEAH-box helicase 36
Mouse
Rat
Dog
DEAH-box helicase 36
Publication Statistics
PubMed Score 74.91
PubMed score by year
PubTator Score 23.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title