Tbio DHX36 ATP-dependent DNA/RNA helicase DHX36

Protein Summary

Description

Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H2U1
• B2RB00
• Q70JU3
• Q8IYE5
• Q9P240

Gene Name

• DHX36

Ensembl ID

• ENST00000308361
• ENSP00000309296
• ENSG00000174953
• ENST00000329463
• ENSP00000330113
• ENST00000496811
• ENSP00000417078

Symbol

• DDX36
• KIAA1488
• MLEL1
• RHAU
• G4R1
• RHAU
• DDX36
• MLEL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.92
virus perturbation	0.88
kinase perturbation	0.84
cell type or tissue	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Atp-dependent Dna/rna Helicase Dhx36

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Atp-dependent Dna/rna Helicase Dhx36

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Atp-dependent Rna Helicase Dhx36

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.91   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.91   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (111)

Explore Interacting Targets

1 – 10 of 111

• See Interactions on String-DB

RPS13

Tbio

Novelty:  0.0019983

p_int:  0.960890599

p_ni:  0.039109401

Data Source:  BioPlex

LARP4B

Tbio

Novelty:  0.11363794

p_int:  0.93950705

p_ni:  0.06049295

Data Source:  BioPlex

RPS16

Tbio

Novelty:  0.00261983

p_int:  0.938720487

p_ni:  0.061279513

Data Source:  BioPlex

FGF8

Tbio

Novelty:  0.00155113

p_int:  0.934577705

p_ni:  0.065422293

p_wrong:  2e-9

Data Source:  BioPlex

ZNF777

Tdark

Family:  TF

Novelty:  1.20195224

p_int:  0.934142012

p_ni:  0.065857988

Data Source:  BioPlex

BYSL

Tbio

Novelty:  0.01919968

p_int:  0.914525657

p_ni:  0.085474342

Score:  0.469

Data Source:  BioPlex,STRINGDB

FGF3

Tbio

Novelty:  0.00474087

p_int:  0.882750118

p_ni:  0.117249882

Data Source:  BioPlex

MAP7

Tbio

Novelty:  0.01976296

p_int:  0.835318692

p_ni:  0.164681308

Data Source:  BioPlex

MRPS18B

Tbio

Novelty:  0.14519418

p_int:  0.834691454

p_ni:  0.165308546

Data Source:  BioPlex

ZBTB38

Tbio

Family:  TF

Novelty:  0.05048192

p_int:  0.784599466

p_ni:  0.215400534

Score:  0.201

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Reactome	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7 targets	R-HSA-3134963
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7 targets	R-HSA-3134963
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (63)

Functions (19)

Components (11)

Processes (33)

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1 – 10 of 19

GO Term	Evidence	Assigned by
ATP-dependent DNA helicase activity	Inferred from Direct Assay (IDA)	UniProtKB
ATP-dependent RNA helicase activity	Inferred from Direct Assay (IDA)	UniProtKB
DNA-dependent ATPase activity	Inferred from Direct Assay (IDA)	UniProtKB
double-stranded RNA binding	Inferred from Direct Assay (IDA)	MGI
G-quadruplex DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
G-quadruplex RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR AU-rich region binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 5'-UTR binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (6)

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1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	4	3	4		86.3
coronary artery disease	EFO_0001645	2	2	2		75.7
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		53.3
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		52
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		39.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	4		86.3
coronary artery disease	EFO_0001645	2		75.7
apolipoprotein A 1 measurement	EFO_0004614	1		53.3
comparative body size at age 10, self-reported	EFO_0009819	1		52
high density lipoprotein cholesterol measurement	EFO_0004612	1		39.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Alternative splicing
Antiviral defense
ATP-binding
Cell projection
Chromosome
Coiled coil
Complete proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
body mass index
comparative body size at age 10, self-reported
coronary artery disease
high density lipoprotein cholesterol measurement
myocardial infarction

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	DEAH-box helicase 36	VGNC:7057	460791
Macaque	DEAH-box helicase 36		708112
Mouse	DEAH (Asp-Glu-Ala-His) box polypeptide 36	MGI:1919412	72162
Rat	DEAH-box helicase 36	RGD:1308767	310461
Dog	DEAH-box helicase 36	VGNC:39946	477117

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DEAH-box helicase 36
Macaque	DEAH-box helicase 36
Mouse	DEAH (Asp-Glu-Ala-His) box polypeptide 36
Rat	DEAH-box helicase 36
Dog	DEAH-box helicase 36

Publication Statistics

PubMed Score 74.91

PubMed score by year

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PubTator Score 23.51

PubTator score by year

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Related Publications

Text Mined References (43)

GeneRif Annotations (20)

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PMID	Year	Title