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Tbio
RANBP17
Ran-binding protein 17

Protein Summary
Description
May function as a nuclear transport receptor. The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389118
  • ENSP00000373770
  • ENSG00000204764
  • ENST00000519256
  • ENSP00000429298
  • ENST00000519949
  • ENSP00000430444
  • ENST00000522533
  • ENSP00000430599
  • ENST00000523189
  • ENSP00000427975
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
interacting protein
0.71
kinase perturbation
0.71
cell type or tissue
0.63
cellular component
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.74   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.74   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0