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Tbio
RANBP17
Ran-binding protein 17

Protein Summary
Description
May function as a nuclear transport receptor. The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389118
  • ENSP00000373770
  • ENSG00000204764
  • ENST00000519256
  • ENSP00000429298
  • ENST00000519949
  • ENSP00000430444
  • ENST00000522533
  • ENSP00000430599
  • ENST00000523189
  • ENSP00000427975
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
interacting protein
0.71
kinase perturbation
0.71
cell type or tissue
0.63
cellular component
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.24   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.24   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
4
86.2
high density lipoprotein cholesterol measurement
2
2
2
73.4
smoking status measurement
2
2
2
70.4
body height
1
1
1
67.9
mathematical ability
3
3
3
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
86.2
high density lipoprotein cholesterol measurement
2
73.4
smoking status measurement
2
70.4
body height
1
67.9
mathematical ability
3
67.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAN binding protein 17
VGNC:4142
739299
Mouse
MGI:1929706
66011
Rat
RGD:1562576
303029
Dog
RAN binding protein 17
VGNC:45338
479293
Horse
RAN binding protein 17
VGNC:22170
100070317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAN binding protein 17
Mouse
Rat
Dog
RAN binding protein 17
Horse
RAN binding protein 17
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2T7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (40)
1 – 10 of 40
GYPB
Tbio
Novelty:  0.00442195
p_int:  1
Score:  0.225
Data Source:  BioPlex,STRINGDB
POLL
Tbio
Family:  Enzyme
Novelty:  0.00244645
Score:  0.756
Data Source:  STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
Score:  0.746
Data Source:  STRINGDB
TLX2
Tbio
Family:  TF
Novelty:  0.01105809
Score:  0.711
Data Source:  STRINGDB
MARCH1
Tbio
Family:  Enzyme
Novelty:  0.02721025
Score:  0.682
Data Source:  STRINGDB
BCL11B
Tbio
Family:  TF
Novelty:  0.00555596
Score:  0.648
Data Source:  STRINGDB
TLX3
Tbio
Family:  TF
Novelty:  0.01152722
Score:  0.631
Data Source:  STRINGDB
LYL1
Tbio
Family:  TF
Novelty:  0.02669155
Score:  0.626
Data Source:  STRINGDB
SPEM1
Tdark
Novelty:  0.28276021
Score:  0.625
Data Source:  STRINGDB
RANBP6
Tdark
Novelty:  0.75714796
Score:  0.591
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.24

PubMed score by year
PubTator Score  6.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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