Protein Summary
May be an angiogenesis inhibitor. This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]
- ENST00000373031
- ENSP00000362122
- ENSG00000000005
- CHM1L
- TEM
- CHM1L
- BRICD4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.92 | ||
cell type or tissue | 0.61 | ||
kinase perturbation | 0.48 | ||
biological process | 0.43 | ||
cell line | 0.43 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.13 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.13 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Gene Ontology Terms (8)
Components (3)
Processes (5)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Protein-Protein Interactions (34)
1 – 10 of 34
SCX
Family: TF
Novelty: 0.01281526
Score: 0.911
Data Source: STRINGDB
GDF7
Novelty: 0.02414837
Score: 0.803
Data Source: STRINGDB
MKX
Novelty: 0.03925784
Score: 0.784
Data Source: STRINGDB
DCN
Novelty: 0.00087842
Score: 0.735
Data Source: STRINGDB
GDF5
Novelty: 0.00262695
Score: 0.732
Data Source: STRINGDB
FMOD
Novelty: 0.00482703
Score: 0.717
Data Source: STRINGDB
MSTN
Novelty: 0.00074387
Score: 0.675
Data Source: STRINGDB
KERA
Novelty: 0.00617227
Score: 0.642
Data Source: STRINGDB
BGN
Novelty: 0.00181025
Score: 0.633
Data Source: STRINGDB
COL1A1
Novelty: 0.00095231
Score: 0.628
Data Source: STRINGDB
Publication Statistics
PubMed Score 99.13
PubMed score by year
PubTator Score 33.49
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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