Tbio TNMD Tenomodulin

Protein Summary

Description

May be an angiogenesis inhibitor. This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q9H2S6
• Q9HBX0
• Q9UJG0
• TeM

Gene Name

• TNMD

Ensembl ID

• ENST00000373031
• ENSP00000362122
• ENSG00000000005

Symbol

• CHM1L
• TEM
• CHM1L
• BRICD4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
cell type or tissue	0.61
kinase perturbation	0.48
biological process	0.43
cell line	0.43

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.48   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.48   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	2	2	2		68.5
mean platelet volume	EFO_0004584	1	1	1		60.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	2		68.5
mean platelet volume	EFO_0004584	1		60.2

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tenomodulin	VGNC:1188	473697
Macaque	tenomodulin		700526
Mouse	tenomodulin	MGI:1929885	64103
Rat	tenomodulin	RGD:620938	64104
Dog	tenomodulin	VGNC:47684	480980

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tenomodulin
Macaque	tenomodulin
Mouse	tenomodulin
Rat	tenomodulin
Dog	tenomodulin

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9H2S6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)

Components (3)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytoplasm	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
nuclear envelope	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (34)

Explore Interacting Targets

1 – 10 of 34

• See Interactions on String-DB

SCX

Tbio

Family:  TF

Novelty:  0.01222743

Score:  0.911

Data Source:  STRINGDB

GDF7

Tbio

Novelty:  0.01726848

Score:  0.803

Data Source:  STRINGDB

MKX

Tbio

Novelty:  0.02160101

Score:  0.784

Data Source:  STRINGDB

DCN

Tbio

Novelty:  0.00073027

Score:  0.735

Data Source:  STRINGDB

GDF5

Tbio

Novelty:  0.00218118

Score:  0.732

Data Source:  STRINGDB

FMOD

Tbio

Novelty:  0.00459438

Score:  0.717

Data Source:  STRINGDB

MSTN

Tclin

Novelty:  0.00062316

Score:  0.675

Data Source:  STRINGDB

KERA

Tbio

Novelty:  0.00789599

Score:  0.642

Data Source:  STRINGDB

BGN

Tbio

Novelty:  0.00139486

Score:  0.633

Data Source:  STRINGDB

COL1A1

Tbio

Novelty:  0.00063584

Score:  0.628

Data Source:  STRINGDB

Publication Statistics

PubMed Score  145.48

PubMed score by year

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PubTator Score  33.49

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Disulfide bond
Glycoprotein
Membrane
Nucleus
Phosphoprotein
Reference proteome
Signal-anchor

GWAS Trait Find Similar Targets

No Header	No Header
mean platelet volume
testosterone measurement

MGI Phenotype Find Similar Targets

No Header	No Header
muscle phenotype
skeleton phenotype