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Tbio
TNMD
Tenomodulin

Protein Summary
Description
May be an angiogenesis inhibitor. This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373031
  • ENSP00000362122
  • ENSG00000000005

Symbol
  • CHM1L
  • TEM
  • CHM1L
  • BRICD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
cell type or tissue
0.61
kinase perturbation
0.48
biological process
0.43
cell line
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.48   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.48   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
68.5
mean platelet volume
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
68.5
mean platelet volume
1
60.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tenomodulin
VGNC:1188
473697
Macaque
tenomodulin
700526
Mouse
MGI:1929885
64103
Rat
RGD:620938
64104
Dog
tenomodulin
VGNC:47684
480980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tenomodulin
Macaque
tenomodulin
Mouse
Rat
Dog
tenomodulin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2S6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (34)
1 – 10 of 34
SCX
Tbio
Family:  TF
Novelty:  0.01222743
Score:  0.911
Data Source:  STRINGDB
GDF7
Tbio
Novelty:  0.01726848
Score:  0.803
Data Source:  STRINGDB
MKX
Tbio
Novelty:  0.02160101
Score:  0.784
Data Source:  STRINGDB
DCN
Tbio
Novelty:  0.00073027
Score:  0.735
Data Source:  STRINGDB
GDF5
Tbio
Novelty:  0.00218118
Score:  0.732
Data Source:  STRINGDB
FMOD
Tbio
Novelty:  0.00459438
Score:  0.717
Data Source:  STRINGDB
MSTN
Tclin
Novelty:  0.00062316
Score:  0.675
Data Source:  STRINGDB
KERA
Tbio
Novelty:  0.00789599
Score:  0.642
Data Source:  STRINGDB
BGN
Tbio
Novelty:  0.00139486
Score:  0.633
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.628
Data Source:  STRINGDB
Publication Statistics
PubMed Score  145.48

PubMed score by year
PubTator Score  33.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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