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Tbio
TNMD
Tenomodulin

Protein Summary
Description
May be an angiogenesis inhibitor. This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373031
  • ENSP00000362122
  • ENSG00000000005

Symbol
  • CHM1L
  • TEM
  • CHM1L
  • BRICD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
cell type or tissue
0.61
kinase perturbation
0.48
biological process
0.43
cell line
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.13   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.13   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (34)
1 – 10 of 34
SCX
Tbio
Family: TF
Novelty: 0.01281526
Score: 0.911
Data Source: STRINGDB
GDF7
Tbio
Novelty: 0.02414837
Score: 0.803
Data Source: STRINGDB
MKX
Tbio
Novelty: 0.03925784
Score: 0.784
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00087842
Score: 0.735
Data Source: STRINGDB
GDF5
Tbio
Novelty: 0.00262695
Score: 0.732
Data Source: STRINGDB
FMOD
Tbio
Novelty: 0.00482703
Score: 0.717
Data Source: STRINGDB
MSTN
Tclin
Novelty: 0.00074387
Score: 0.675
Data Source: STRINGDB
KERA
Tbio
Novelty: 0.00617227
Score: 0.642
Data Source: STRINGDB
BGN
Tbio
Novelty: 0.00181025
Score: 0.633
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00095231
Score: 0.628
Data Source: STRINGDB
Publication Statistics
PubMed Score  99.13

PubMed score by year
PubTator Score  33.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer