Tbio RNF39 RING finger protein 39

Protein Summary

Description

May play a role in prolonged long term-potentiation (LTP) maintenance. This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H2S5
• A2BEK3
• A6NCD6
• B0S858
• Q5SPM8
• Q5SPM9
• Q5SPN0
• Q5SRJ9
• Q5SRK1
• Q5SS29
• Q9H2S3
• Q9H2S4

Gene Name

• RNF39

Ensembl ID

• ENST00000244360
• ENSP00000244360
• ENSG00000204618
• ENST00000376750
• ENSP00000365941
• ENSG00000206500
• ENST00000376751
• ENSP00000365942
• ENST00000417541
• ENSP00000407248
• ENSG00000237733
• ENST00000425956
• ENSP00000393560
• ENSG00000227171
• ENST00000432647
• ENSP00000398512
• ENSG00000230332
• ENST00000441449
• ENSP00000392508
• ENSG00000236967
• ENST00000442063
• ENSP00000415281
• ENSG00000235022
• ENST00000442378
• ENSP00000401131
• ENST00000449145
• ENSP00000408539
• ENST00000450015
• ENSP00000407291
• ENST00000451425
• ENSP00000391822
• ENST00000456156
• ENSP00000395696
• ENST00000457092
• ENSP00000405340
• ENSG00000230467

Symbol

• HZFW
• HZF
• HZFW
• LIRF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
gene perturbation	0.66
small molecule perturbation	0.62
phenotype	0.56
tissue sample	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.16   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.16   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0