KCNN2
Small conductance calcium-activated potassium channel protein 2
Protein Summary
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding ...more
- ENST00000264773
- ENSP00000264773
- ENSG00000080709
- ENST00000503706
- ENSP00000421439
- ENST00000610748
- ENSP00000483124
- SK2
- hSK2
- SKCA2
- KCa2.2
- SKCa 2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.94 | ||
transcription factor | 0.77 | ||
histone modification site profile | 0.74 | ||
ligand (chemical) | 0.7 | ||
tissue sample | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.35 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 106 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.35 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 106 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 25
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (25)
Protein-Protein Interactions (58)
Nearest Tclin Targets
Pathways (62)
Reactome (3)
KEGG (4)
WikiPathways (55)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ca2+ activated K+ channels | ||||
Reactome | Neuronal System | ||||
Reactome | Potassium Channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ca2+ activated K+ channels | ||||
Neuronal System | ||||
Potassium Channels | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (6)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 6 | 5 | 5.5 | 92 | ||||
mathematical ability | 3 | 3 | 4 | 84.6 | |||||
3 | 3 | 0 | 1.1 | 82.9 | |||||
intelligence | 3 | 4 | 3 | 5.5 | 73.8 | ||||
1 | 2 | 2 | 58.2 | ||||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 5 | 5.5 | 92 | ||||
mathematical ability | 4 | 84.6 | |||||
0 | 1.1 | 82.9 | |||||
intelligence | 3 | 5.5 | 73.8 | ||||
2 | 58.2 | ||||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 2 | VGNC:13523 | 462006 | |||||
Macaque | potassium calcium-activated channel subfamily N member 2 | 695374 | ||||||
Mouse | MGI:2153182 | 140492 | ||||||
Rat | RGD:2963 | 54262 | ||||||
Dog | potassium calcium-activated channel subfamily N member 2 | VGNC:42285 | 474640 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 2 | |||||
Macaque | potassium calcium-activated channel subfamily N member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium calcium-activated channel subfamily N member 2 | |||||
Publication Statistics
PubMed Score 52.35
PubMed score by year
PubTator Score 67.94
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (32)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
|---|