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Tchem
KCNN2
Small conductance calcium-activated potassium channel protein 2

Protein Summary
Description
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264773
  • ENSP00000264773
  • ENSG00000080709
  • ENST00000503706
  • ENSP00000421439
  • ENST00000610748
  • ENSP00000483124

Symbol
  • SK2
  • hSK2
  • SKCA2
  • KCa2.2
  • SKCa 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor
0.77
histone modification site profile
0.74
ligand (chemical)
0.7
tissue sample
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.35   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.35   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (58)
CALM1
Tclin
Novelty:  0.00308267
Score:  0.987
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.985
Data Source:  STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.97
Data Source:  STRINGDB
KCNMA1
Tclin
Family:  IC
Novelty:  0.00088182
Score:  0.947
Data Source:  STRINGDB
KCNMB4
Tbio
Family:  IC
Novelty:  0.05362954
Score:  0.925
Data Source:  STRINGDB
KCNU1
Tbio
Family:  IC
Novelty:  0.02284336
Score:  0.903
Data Source:  STRINGDB
KCND2
Tclin
Family:  IC
Novelty:  0.00297203
Score:  0.896
Data Source:  STRINGDB
KCNMB1
Tbio
Family:  IC
Novelty:  0.00736653
Score:  0.876
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.813
Data Source:  STRINGDB
KCNMB3
Tbio
Family:  IC
Novelty:  0.08717845
Score:  0.812
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (62)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Neuronal System
Potassium Channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
6
5
5.5
92
mathematical ability
3
3
4
84.6
3
3
0
1.1
82.9
intelligence
3
4
3
5.5
73.8
1
2
2
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
5.5
92
mathematical ability
4
84.6
0
1.1
82.9
intelligence
3
5.5
73.8
2
58.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily N member 2
VGNC:13523
462006
Macaque
potassium calcium-activated channel subfamily N member 2
695374
Mouse
MGI:2153182
140492
Rat
RGD:2963
54262
Dog
potassium calcium-activated channel subfamily N member 2
VGNC:42285
474640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily N member 2
Macaque
potassium calcium-activated channel subfamily N member 2
Mouse
Rat
Dog
potassium calcium-activated channel subfamily N member 2
Publication Statistics
PubMed Score 52.35
PubMed score by year
PubTator Score 67.94
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title