Tchem KCNN2 Small conductance calcium-activated potassium channel protein 2

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Potassium Channel / Small Conductance Calcium-activated Potassium Channel Protein 2

Protein / Transporter / Ion Channel / Potassium Channel / Voltage-gated Potassium Channel / Small Conductance Calcium-activated Potassium Channel Protein 2

Protein Summary

Description

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q9H2S1
• A6NF94
• Q0VFZ4
• Q6PJI0
• Q6X2Y2
• SK2

Gene Name

• KCNN2

Ensembl ID

• ENST00000264773
• ENSP00000264773
• ENSG00000080709
• ENST00000503706
• ENSP00000421439
• ENST00000610748
• ENSP00000483124

Symbol

• SK2
• hSK2
• SKCA2
• KCa2.2
• SKCa 2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
transcription factor	0.77
histone modification site profile	0.74
ligand (chemical)	0.7
tissue sample	0.7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.14   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.14   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

tubocurarine

KCNN2Tchem IC

BLOCKER IC50: 5.7

riluzole

KCNN2Tchem IC

EC50: 4.88999987

Active Ligands (25)

Explore Active Ligands

1 – 10 of 25

CHEMBL444449

KCNN2Tchem IC

EC50: 5.3

tetraethylammonium

KCNN2Tchem IC

-: 2.70000005

CHEMBL510780

KCNN2Tchem IC

-: 6.19999981

CHEMBL511710

KCNN2Tchem IC

Kd: 7.33

CHEMBL489770

KCNN2Tchem IC

IC50: 6.91

CHEMBL476339

KCNN2Tchem IC

IC50: 7.96

CHEMBL45193

KCNN2Tchem IC

-: 9.60000038

CHEMBL452406

KCNN2Tchem IC

IC50: 5.96

CHEMBL472452

KCNN2Tchem IC

IC50: 6.28

CHEMBL612120

KCNN2Tchem IC

-: 9.60000038

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (62)

Reactome (3)

KEGG (4)

WikiPathways (55)

Ca2+ activated K+ channels (R-HSA-1296052)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Ca2+ activated K+ channels	9 targets	R-HSA-1296052
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Potassium Channels	99 targets	R-HSA-1296071

Name	Explore in Pharos	Explore in Source
Ca2+ activated K+ channels	9 targets	R-HSA-1296052
Neuronal System	398 targets	R-HSA-112316
Potassium Channels	99 targets	R-HSA-1296071

Gene Ontology Terms (17)

Functions (6)

Components (7)

Processes (4)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
calcium-activated potassium channel activity	Inferred from Direct Assay (IDA)	BHF-UCL
small conductance calcium-activated potassium channel activity	Inferred from Direct Assay (IDA)	BHF-UCL
alpha-actinin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
calmodulin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (58)

Explore Interacting Targets

1 – 10 of 58

• See Interactions on String-DB

CALM1

Tclin

Novelty: 0.00331843

Score: 0.987

Data Source: STRINGDB

CALM3

Tclin

Novelty: 0.0082907

Score: 0.985

Data Source: STRINGDB

CALM2

Tclin

Novelty: 0.02810502

Score: 0.97

Data Source: STRINGDB

KCNMA1

Tclin

Family: IC

Novelty: 0.00067067

Score: 0.947

Data Source: STRINGDB

KCNMB4

Tbio

Family: IC

Novelty: 0.09644792

Score: 0.925

Data Source: STRINGDB

KCNU1

Tbio

Family: IC

Novelty: 0.01936198

Score: 0.903

Data Source: STRINGDB

KCND2

Tclin

Family: IC

Novelty: 0.00380702

Score: 0.896

Data Source: STRINGDB

KCNMB1

Tbio

Family: IC

Novelty: 0.01165598

Score: 0.876

Data Source: STRINGDB

KCNN4

Tchem

Family: IC

Novelty: 0.00319428

Score: 0.813

Data Source: STRINGDB

KCNMB3

Tbio

Family: IC

Novelty: 0.18426318

Score: 0.812

Data Source: STRINGDB

Publication Statistics

PubMed Score  22.14

PubMed score by year

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PubTator Score  67.94

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSK

1-70

PEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALI

70-140

FGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMT

140-210

YERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLF

210-280

TDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMW

280-350

LISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK

350-420

NAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMY

420-490

DMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRS

490-560

SSRRRRSSSTAPPTSSESS

560-579

MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Calmodulin-binding
Complete proteome
Ion channel
Ion transport
Membrane
Phosphoprotein
Reference proteome
Transmembrane