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Tbio
RASSF4
Ras association domain-containing protein 4

Protein Summary
Description
Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest. The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340258
  • ENSP00000339692
  • ENSG00000107551

Symbol
  • AD037
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.88
cellular component
0.76
histone modification site profile
0.64
PubMedID
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.72   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.72   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
Score:  0.959
Data Source:  STRINGDB
RASSF2
Tbio
Novelty:  0.031565
Score:  0.814
Data Source:  STRINGDB
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
Score:  0.806
Data Source:  STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
Score:  0.679
Data Source:  STRINGDB
SAV1
Tbio
Novelty:  0.00962335
Score:  0.633
Data Source:  STRINGDB
RASSF5
Tbio
Novelty:  0.01035881
Score:  0.629
Data Source:  STRINGDB
RASSF3
Tbio
Novelty:  0.25970783
Score:  0.614
Data Source:  STRINGDB
RASSF8
Tbio
Novelty:  0.09245647
Score:  0.578
Data Source:  STRINGDB
RASSF10
Tbio
Novelty:  0.05161283
Score:  0.533
Data Source:  STRINGDB
MST1
Tchem
Family:  Enzyme
Novelty:  0.00781564
Score:  0.523
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
2
2
95.2
mean corpuscular volume
2
2
2
93.7
reticulocyte measurement
3
2
3
89.3
mean reticulocyte volume
1
1
1
84.3
erythrocyte count
1
1
1
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
95.2
mean corpuscular volume
2
93.7
reticulocyte measurement
3
89.3
mean reticulocyte volume
1
84.3
erythrocyte count
1
82
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Ras association domain family member 4
706096
Mouse
MGI:2386853
213391
Rat
RGD:1307785
362423
Dog
Ras association domain family member 4
VGNC:45381
607383
Horse
Ras association domain family member 4
VGNC:22211
100049802
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Ras association domain family member 4
Mouse
Rat
Dog
Ras association domain family member 4
Horse
Ras association domain family member 4
Publication Statistics
PubMed Score 2.72
PubMed score by year
PubTator Score 9.77
PubTator score by year
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Related Publications
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PMID
Year
Title