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Tdark
TMEM60
Transmembrane protein 60

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257663
  • ENSP00000257663
  • ENSG00000135211

Symbol
  • C7orf35
  • DC32
  • C7orf35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
histone modification site profile
0.88
transcription factor binding site profile
0.85
disease perturbation
0.79
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
WDR37
Tbio
Novelty:  0.1677975
Score:  0.827
Data Source:  STRINGDB
FAM229B
Tdark
Novelty:  6.66666667
Score:  0.78
Data Source:  STRINGDB
WDR72
Tbio
Novelty:  0.07576018
Score:  0.73
Data Source:  STRINGDB
IQCF1
Tdark
Novelty:  0.78525464
Score:  0.707
Data Source:  STRINGDB
MSANTD4
Tdark
Novelty:  0.09434234
Score:  0.64
Data Source:  STRINGDB
GATM
Tbio
Family:  Enzyme
Novelty:  0.00340356
Score:  0.627
Data Source:  STRINGDB
SLC6A12
Tchem
Family:  Transporter
Novelty:  0.00751471
Score:  0.619
Data Source:  STRINGDB
TMEM203
Tdark
Novelty:  0.79245283
Score:  0.61
Data Source:  STRINGDB
SFT2D1
Tdark
Novelty:  0.56703167
Score:  0.583
Data Source:  STRINGDB
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
Score:  0.576
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
6
5
8
96.4
BMI-adjusted waist-hip ratio
3
7
7
92.7
waist-hip ratio
3
5
6
84.4
sex hormone-binding globulin measurement
2
1
2
71.9
eosinophil count
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
8
96.4
BMI-adjusted waist-hip ratio
7
92.7
waist-hip ratio
6
84.4
sex hormone-binding globulin measurement
2
71.9
eosinophil count
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 60
VGNC:4544
463496
Macaque
transmembrane protein 60
693679
Mouse
MGI:2673965
212090
Dog
transmembrane protein 60
VGNC:47592
100685779
Horse
transmembrane protein 60
VGNC:24304
100049981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 60
Macaque
transmembrane protein 60
Mouse
Dog
transmembrane protein 60
Horse
transmembrane protein 60
Publication Statistics
PubMed Score 2.32
PubMed score by year
PubTator Score 0.61
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title