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Tchem
TAOK3
Serine/threonine-protein kinase TAO3

Protein Summary
Description
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392533
  • ENSP00000376317
  • ENSG00000135090
  • ENST00000419821
  • ENSP00000416374

Symbol
  • DPK
  • JIK
  • KDS
  • MAP3K18
  • DPK
  • JIK
  • hKFC-A
  • MAP3K18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.91
biological process
0.9
virus perturbation
0.9
small molecule
0.89


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.8   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.8   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
89.9
neuroticism measurement
4
3
2
6.3
63.1
wellbeing measurement
2
2
2
46.1
depressive symptom measurement
1
1
1
33.1
loneliness measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
89.9
neuroticism measurement
2
6.3
63.1
wellbeing measurement
2
46.1
depressive symptom measurement
1
33.1
loneliness measurement
1
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TAO kinase 3
677710
Mouse
MGI:3041177
330177
Rat
RGD:1562861
304530
Dog
TAO kinase 3
VGNC:47104
477502
Horse
TAO kinase 3
VGNC:23870
100050932
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TAO kinase 3
Mouse
Rat
Dog
TAO kinase 3
Horse
TAO kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2K8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (27)
1 – 10 of 27
BTN3A1
Tchem
Novelty:  0.02572232
p_int:  0.999998338
p_ni:  4e-9
p_wrong:  0.000001657
Data Source:  BioPlex
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.939
Data Source:  STRINGDB
MAP2K3
Tchem
Family:  Kinase
Novelty:  0.00349605
Score:  0.909
Data Source:  STRINGDB
MAP2K6
Tchem
Family:  Kinase
Novelty:  0.00569655
Score:  0.906
Data Source:  STRINGDB
TAOK1
Tchem
Family:  Kinase
Novelty:  0.01714291
Score:  0.903
Data Source:  STRINGDB
TAOK2
Tchem
Family:  Kinase
Novelty:  0.0232708
Score:  0.901
Data Source:  STRINGDB
KDSR
Tbio
Family:  Enzyme
Novelty:  0.0408411
Score:  0.901
Data Source:  STRINGDB
APPBP2
Tbio
Novelty:  0.14742368
Score:  0.648
Data Source:  STRINGDB
C16orf58
Tdark
Novelty:  0.34461652
Score:  0.556
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.539
Data Source:  STRINGDB
Publication Statistics
PubMed Score  50.80

PubMed score by year
PubTator Score  27.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer