Protein Summary
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
- ENST00000371627
- ENSP00000360689
- ENSG00000107854
- PARP5B
- TANK2
- TNKL
- TNKL
- ARTD6
- TANK2
- pART6
- PARP5B
- PARP5C
- PARP-5b
- PARP-5c
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
protein domain | 0.85 | ||
cellular component | 0.77 | ||
transcription factor perturbation | 0.74 | ||
transcription factor binding site profile | 0.73 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.23 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 209 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.23 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 209 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 339
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
Active Ligands (339)
1 – 10 of 339
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 99.1 | |||||
testosterone measurement | 2 | 2 | 2 | 83.8 | |||||
1 | 1 | 0 | 1.3 | 72.8 | |||||
neutrophil count | 2 | 2 | 2 | 57.6 | |||||
myeloid white cell count | 1 | 1 | 1 | 6.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 99.1 | |||||
testosterone measurement | 2 | 83.8 | |||||
0 | 1.3 | 72.8 | |||||
neutrophil count | 2 | 57.6 | |||||
myeloid white cell count | 1 | 6.7 | |||||
Protein Data Bank (146)
1 – 5 of 146
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (23)
Reactome (16)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 16
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of AXIN | ||||
Reactome | Deubiquitination | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Intracellular signaling by second messengers | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of AXIN | ||||
Deubiquitination | ||||
Disease | ||||
Diseases of signal transduction | ||||
Intracellular signaling by second messengers | ||||
Gene Ontology Terms (22)
Functions (3)
Components (8)
Processes (11)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (115)
1 – 10 of 115
PAGE4
Novelty: 0.05404149
p_int: 0.999999971
p_ni: 2.9e-8
Data Source: BioPlex
HIF1AN
Novelty: 0.00861018
p_int: 0.999999935
p_ni: 6.5e-8
Score: 0.908
Data Source: BioPlex,STRINGDB
BABAM1
Novelty: 0.03812501
p_int: 0.999999654
p_ni: 3.46e-7
Score: 0.341
Data Source: BioPlex,STRINGDB
GMDS
Family: Enzyme
Novelty: 0.00622275
p_int: 0.99999891
p_ni: 0.00000109
Score: 0.827
Data Source: BioPlex,STRINGDB
SSSCA1
Novelty: 0.53523038
p_int: 0.999998775
p_ni: 0.000001223
p_wrong: 1e-9
Data Source: BioPlex
FAM117B
Novelty: 1.06316483
p_int: 0.999998536
p_ni: 0.000001464
Data Source: BioPlex
RNF166
Novelty: 0.71460884
p_int: 0.999997572
p_ni: 0.000002428
Data Source: BioPlex
PPP1R12B
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999997458
p_ni: 0.000002541
Data Source: BioPlex
SH3BP5L
Novelty: 1.7921497
p_int: 0.999996413
p_ni: 0.000003587
Data Source: BioPlex
EPN3
Novelty: 0.12685855
p_int: 0.999980638
p_ni: 0.000019362
Score: 0.159
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 83.23
PubMed score by year
PubTator Score 443.51
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
GWAS Trait