Protein Summary
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
- ENST00000371627
- ENSP00000360689
- ENSG00000107854
- PARP5B
- TANK2
- TNKL
- TNKL
- ARTD6
- TANK2
- pART6
- PARP5B
- PARP5C
- PARP-5b
- PARP-5c
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
protein domain | 0.85 | ||
cellular component | 0.77 | ||
transcription factor perturbation | 0.74 | ||
transcription factor binding site profile | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.12 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 209 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.12 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 209 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 523
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (523)
Protein-Protein Interactions (115)
HIF1AN
Novelty: 0.00861018
p_int: 0.999999935
p_ni: 6.5e-8
Score: 0.908
Data Source: BioPlex,STRINGDB
BABAM1
Novelty: 0.03812501
p_int: 0.999999654
p_ni: 3.46e-7
Score: 0.341
Data Source: BioPlex,STRINGDB
GMDS
Family: Enzyme
Novelty: 0.00622275
p_int: 0.99999891
p_ni: 0.00000109
Score: 0.827
Data Source: BioPlex,STRINGDB
SSSCA1
Novelty: 0.53523038
p_int: 0.999998775
p_ni: 0.000001223
p_wrong: 1e-9
Data Source: BioPlex
PPP1R12B
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999997458
p_ni: 0.000002541
Data Source: BioPlex
EPN3
Novelty: 0.12685855
p_int: 0.999980638
p_ni: 0.000019362
Score: 0.159
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (23)
Reactome (16)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of AXIN | ||||
Reactome | Deubiquitination | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Intracellular signaling by second messengers | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of AXIN | ||||
Deubiquitination | ||||
Disease | ||||
Diseases of signal transduction | ||||
Intracellular signaling by second messengers | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (3)
Components (8)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 93.6 | |||||
1 | 1 | 0 | 1.3 | 78.4 | |||||
alkaline phosphatase measurement | 2 | 2 | 1 | 6.5 | 70.1 | ||||
testosterone measurement | 2 | 2 | 2 | 62 | |||||
neutrophil count | 2 | 2 | 2 | 56.2 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 93.6 | |||||
0 | 1.3 | 78.4 | |||||
alkaline phosphatase measurement | 1 | 6.5 | 70.1 | ||||
testosterone measurement | 2 | 62 | |||||
neutrophil count | 2 | 56.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tankyrase 2 | VGNC:8886 | 100609110 | |||||
Macaque | tankyrase 2 | 698050 | ||||||
Mouse | MGI:1921743 | 74493 | ||||||
Rat | RGD:6496922 | 100910717 | ||||||
Dog | tankyrase 2 | VGNC:47683 | 100855568 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tankyrase 2 | |||||
Macaque | tankyrase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tankyrase 2 | |||||
Publication Statistics
PubMed Score 90.12
PubMed score by year
PubTator Score 443.51
PubTator score by year
Related Publications
Text Mined References (49)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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