Tchem TNKS2 Tankyrase-2

Protein Summary

Description

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Uniprot Accession IDs

• Q9H2K2
• B2RBD3
• Q9H8F2
• Q9HAS4
• TANK2

Gene Name

• TNKS2

Ensembl ID

• ENST00000371627
• ENSP00000360689
• ENSG00000107854

Symbol

• PARP5B
• TANK2
• TNKL
• TNKL
• ARTD6
• TANK2
• pART6
• PARP5B
• PARP5C
• PARP-5b
• PARP-5c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
protein domain	0.85
cellular component	0.77
transcription factor perturbation	0.74
transcription factor binding site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.29   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.29   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 547

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3