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Tdark
LRMDA
Leucine-rich melanocyte differentiation-associated protein

Protein Summary
Description
Required for melanocyte differentiation. This gene encodes a leucine-rich repeat protein. The encoded protein is thought to play a role in melanocyte differentiation. Mutations in this gene have been associated with autosomal recessive oculocutaneous albinism 7 (OCA7). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372499
  • ENSP00000361577
  • ENSG00000148655

Symbol
  • CDA017
  • C10orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
8
8
98.8
Alopecia
1
6
6
92
forced expiratory volume
3
2
3
90.9
heel bone mineral density
2
3
5
85.4
hematocrit
2
4
4
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
8
98.8
Alopecia
6
92
forced expiratory volume
3
90.9
heel bone mineral density
5
85.4
hematocrit
4
84.3
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich melanocyte differentiation associated
VGNC:3818
739123
Mouse
MGI:1923883
76633
Dog
leucine rich melanocyte differentiation associated [Source:HGNC Symbol;Acc:HGNC:23405]
Zebrafish
ZDB-GENE-050522-285
553730
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich melanocyte differentiation associated
Mouse
Dog
leucine rich melanocyte differentiation associated [Source:HGNC Symbol;Acc:HGNC:23405]
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2I8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (148)
1 – 10 of 148
RBM25
Tbio
Novelty:  0.05557892
Score:  0.901
Data Source:  STRINGDB
TXNL4B
Tbio
Novelty:  0.00695407
Score:  0.877
Data Source:  STRINGDB
SF3B3
Tchem
Novelty:  0.02866311
Score:  0.864
Data Source:  STRINGDB
SF3B1
Tbio
Novelty:  0.0128965
Score:  0.848
Data Source:  STRINGDB
CWC25
Tdark
Novelty:  0.13727856
Score:  0.847
Data Source:  STRINGDB
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
Score:  0.846
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.846
Data Source:  STRINGDB
SNRPD3
Tbio
Novelty:  0.02022419
Score:  0.846
Data Source:  STRINGDB
SF3B2
Tbio
Novelty:  0.0271365
Score:  0.841
Data Source:  STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
Score:  0.835
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.56

PubMed score by year
PubTator Score  4.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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