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Tbio
PPIL3
Peptidyl-prolyl cis-trans isomerase-like 3

Protein Classes
Protein Summary
Description
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286175
  • ENSP00000286175
  • ENSG00000240344
  • ENST00000392283
  • ENSP00000376107
  • ENST00000409449
  • ENSP00000387012

Symbol
  • CYPJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.83
kinase perturbation
0.66
tissue sample
0.62
small molecule perturbation
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.17   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.17   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 3
VGNC:14344
459866
Macaque
peptidylprolyl isomerase like 3
700456
Mouse
MGI:1917475
70225
Rat
RGD:631415
301432
Dog
peptidylprolyl isomerase like 3
607430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 3
Macaque
peptidylprolyl isomerase like 3
Mouse
Rat
Dog
peptidylprolyl isomerase like 3
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H2H8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (243)
1 – 10 of 243
SLU7
Tbio
Novelty: 0.0366131
p_int: 0.999999996
p_ni: 4e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
GPALPP1
Tdark
Novelty: 13.22858591
p_int: 0.999998914
p_ni: 0.000001081
p_wrong: 4e-9
Data Source: BioPlex
PLCL2
Tbio
Family: Enzyme
Novelty: 0.13454277
p_int: 0.997486978
p_ni: 1.2e-8
p_wrong: 0.002513011
Data Source: BioPlex
PCBP1
Tbio
Novelty: 0.00906713
Score: 0.977
Data Source: STRINGDB
CWC15
Tbio
Novelty: 0.00205068
Score: 0.971
Data Source: STRINGDB
CRNKL1
Tbio
Novelty: 0.10274174
Score: 0.969
Data Source: STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
Score: 0.969
Data Source: STRINGDB
PRPF38A
Tbio
Novelty: 0.10698531
Score: 0.965
Data Source: STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
Score: 0.964
Data Source: STRINGDB
SNW1
Tbio
Novelty: 0.01423797
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.17

PubMed score by year
PubTator Score  40.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer