You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TSPYL2
Testis-specific Y-encoded-like protein 2

Protein Summary
Description
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375442
  • ENSP00000364591
  • ENSG00000184205

Symbol
  • CDA1
  • DENTT
  • TSPX
  • CDA1
  • CTCL
  • NP79
  • TSPX
  • CINAP
  • DENTT
  • SE204
  • HRIHFB2216
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
cellular component
0.75
transcription factor
0.67
small molecule perturbation
0.6
histone modification site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.28   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.28   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.999999837
p_ni:  1.63e-7
Score:  0.579
Data Source:  BioPlex,STRINGDB
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.999997988
p_ni:  0.000002012
Score:  0.173
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.99866554
p_ni:  0.001327028
p_wrong:  0.000007432
Score:  0.155
Data Source:  BioPlex,STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
p_int:  0.997450698
p_ni:  0.002549302
Data Source:  BioPlex
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.995494695
p_ni:  0.004503972
p_wrong:  0.000001332
Score:  0.22
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.98862256
p_ni:  0.011377435
p_wrong:  5e-9
Score:  0.266
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.960847734
p_ni:  0.038398301
p_wrong:  0.000753965
Data Source:  BioPlex
RPL7
Tbio
Novelty:  0.00552644
p_int:  0.956403791
p_ni:  0.043559225
p_wrong:  0.000036984
Score:  0.198
Data Source:  BioPlex,STRINGDB
SET
Tbio
Novelty:  0.01012327
p_int:  0.95468546
p_ni:  0.045314539
Score:  0.201
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.931308912
p_ni:  0.068690963
p_wrong:  1.25e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106244
52808
Rat
RGD:1563283
302612
Dog
TSPY like 2
VGNC:47928
491893
Horse
TSPY like 2
VGNC:24599
100061180
Cow
TSPY like 2
VGNC:36445
617179
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TSPY like 2
Horse
TSPY like 2
Cow
TSPY like 2
Publication Statistics
PubMed Score 38.28
PubMed score by year
PubTator Score 842.89
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title