Tchem SLK STE20-like serine/threonine-protein kinase

Protein Summary

Description

Mediates apoptosis and actin stress fiber dissolution.

Uniprot Accession IDs

• Q9H2G2
• D3DRA0
• D3DRA1
• O00211
• Q6P1Z4
• Q86WU7
• Q86WW1
• Q92603
• Q9NQL0
• Q9NQL1
• STE20-like kinase

Gene Name

• SLK

Ensembl ID

• ENST00000335753
• ENSP00000336824
• ENSG00000065613
• ENST00000369755
• ENSP00000358770

Symbol

• KIAA0204
• STK2
• LOSK
• STK2
• se20-9
• bA16H23.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
small molecule	0.99
molecular function	0.98
transcription factor perturbation	0.94
protein domain	0.92

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Slk Subfamily / Ste20-like Serine/threonine-protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.49   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.49   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3