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Tchem
SLK
STE20-like serine/threonine-protein kinase

Protein Summary
Description
Mediates apoptosis and actin stress fiber dissolution.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335753
  • ENSP00000336824
  • ENSG00000065613
  • ENST00000369755
  • ENSP00000358770

Symbol
  • KIAA0204
  • STK2
  • LOSK
  • STK2
  • se20-9
  • bA16H23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
small molecule
0.99
molecular function
0.98
transcription factor perturbation
0.94
protein domain
0.92


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.49   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.49   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
5
4
5
91.8
3
3
1
1.1
87.5
mean corpuscular volume
3
3
3
86.8
4
3
0
1.2
79.3
mean reticulocyte volume
1
1
1
74.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
5
91.8
1
1.1
87.5
mean corpuscular volume
3
86.8
0
1.2
79.3
mean reticulocyte volume
1
74.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STE20 like kinase
VGNC:5785
450716
Macaque
STE20 like kinase
715086
Mouse
MGI:103241
20874
Rat
RGD:3780
54308
Dog
STE20 like kinase
VGNC:46512
486876
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STE20 like kinase
Macaque
STE20 like kinase
Mouse
Rat
Dog
STE20 like kinase
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H2G2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
MRPL43
Tdark
Novelty:  0.22331841
p_int:  0.999994697
p_ni:  0.000005303
Score:  0.241
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999181301
p_ni:  0.000818484
p_wrong:  2.15e-7
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.99863142
p_ni:  0.001368565
p_wrong:  1.5e-8
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.997774281
p_ni:  0.002219984
p_wrong:  0.000005736
Score:  0.17
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.994014309
p_ni:  0.000054404
p_wrong:  0.005931286
Data Source:  BioPlex
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.952809875
p_ni:  0.003253827
p_wrong:  0.043936298
Data Source:  BioPlex
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.938
Data Source:  STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
Score:  0.873
Data Source:  STRINGDB
SFN
Tbio
Novelty:  0.00340233
Score:  0.866
Data Source:  STRINGDB
PITHD1
Tdark
Novelty:  0.32046117
Score:  0.86
Data Source:  STRINGDB
Publication Statistics
PubMed Score  336.49

PubMed score by year
PubTator Score  69.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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