Tbio CCDC68 Coiled-coil domain-containing protein 68

Protein Summary

Description

Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).

Uniprot Accession IDs

• Q9H2F9
• B2R9I3

Gene Name

• CCDC68

Ensembl ID

• ENST00000337363
• ENSP00000337209
• ENSG00000166510
• ENST00000432185
• ENSP00000413406
• ENST00000591504
• ENSP00000466690

Symbol

• SE57-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
PubMedID	0.65
kinase perturbation	0.54
histone modification site profile	0.53
tissue sample	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0