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Tbio
HSD3B7
3 beta-hydroxysteroid dehydrogenase type 7

Protein Summary
Description
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to ne ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262520
  • ENSP00000262520
  • ENSG00000099377
  • ENST00000297679
  • ENSP00000297679

Symbol
  • CBAS1
  • PFIC4
  • SDR11E3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.75
kinase perturbation
0.71
tissue sample
0.65
histone modification site profile
0.6
pathway
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
CYP7B1
Tbio
Family:  Enzyme
Novelty:  0.01164653
Score:  0.98
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.977
Data Source:  STRINGDB
AKR1D1
Tbio
Family:  Enzyme
Novelty:  0.01264297
Score:  0.977
Data Source:  STRINGDB
CYP8B1
Tchem
Family:  Enzyme
Novelty:  0.01243408
Score:  0.968
Data Source:  STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.911
Data Source:  STRINGDB
CH25H
Tbio
Family:  Enzyme
Novelty:  0.01620877
Score:  0.809
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.709
Data Source:  STRINGDB
LSS
Tchem
Family:  Enzyme
Novelty:  0.00735187
Score:  0.706
Data Source:  STRINGDB
FDFT1
Tchem
Family:  Enzyme
Novelty:  0.00225882
Score:  0.683
Data Source:  STRINGDB
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
Score:  0.666
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.2
83.8
mean reticulocyte volume
1
1
1
82.8
mean corpuscular volume
1
1
1
82.2
response to anticoagulant
1
1
0
20.4
81
triglyceride measurement
2
2
1
2.1
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83.8
mean reticulocyte volume
1
82.8
mean corpuscular volume
1
82.2
response to anticoagulant
0
20.4
81
triglyceride measurement
1
2.1
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
VGNC:13757
454059
Mouse
MGI:2141879
101502
Dog
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
VGNC:41811
489917
Horse
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
VGNC:18890
100063491
Cow
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
VGNC:29978
540229
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Mouse
Dog
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Horse
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Cow
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Publication Statistics
PubMed Score 21.20
PubMed score by year
PubTator Score 16.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title