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Tbio
HSD3B7
3 beta-hydroxysteroid dehydrogenase type 7

Protein Summary
Description
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to ne ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262520
  • ENSP00000262520
  • ENSG00000099377
  • ENST00000297679
  • ENSP00000297679

Symbol
  • CBAS1
  • PFIC4
  • SDR11E3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.75
kinase perturbation
0.71
tissue sample
0.65
histone modification site profile
0.6
pathway
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.08   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.08   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
irritability measurement
1
1
0
5.8
19.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
irritability measurement
0
5.8
19.5
Pathways (11)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (59)
1 – 10 of 59
CYP7B1
Tbio
Family: Enzyme
Novelty: 0.01164653
Score: 0.98
Data Source: STRINGDB
CYP7A1
Tbio
Family: Enzyme
Novelty: 0.00148194
Score: 0.977
Data Source: STRINGDB
AKR1D1
Tbio
Family: Enzyme
Novelty: 0.01264297
Score: 0.977
Data Source: STRINGDB
CYP8B1
Tbio
Family: Enzyme
Novelty: 0.01243408
Score: 0.968
Data Source: STRINGDB
POR
Tbio
Family: Enzyme
Novelty: 0.00145147
Score: 0.911
Data Source: STRINGDB
CH25H
Tbio
Family: Enzyme
Novelty: 0.01620877
Score: 0.809
Data Source: STRINGDB
SQLE
Tchem
Family: Enzyme
Novelty: 0.0059338
Score: 0.709
Data Source: STRINGDB
LSS
Tchem
Family: Enzyme
Novelty: 0.00735187
Score: 0.706
Data Source: STRINGDB
FDFT1
Tchem
Family: Enzyme
Novelty: 0.00225882
Score: 0.683
Data Source: STRINGDB
HSD17B7
Tchem
Family: Enzyme
Novelty: 0.04295724
Score: 0.666
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.08

PubMed score by year
PubTator Score  16.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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