Protein Summary
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity). The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
- ENST00000343348
- ENSP00000345512
- ENSG00000092421
- ENST00000510263
- ENSP00000424388
- KIAA1368
- SEMAQ
- VIA
- SEMA
- HT018
- SEMAQ
- SEMA6A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.97 | ||
transcription factor perturbation | 0.94 | ||
transcription factor binding site profile | 0.9 | ||
protein domain | 0.73 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 151.41 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 281 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 151.41 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 281 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (117)
NCK2
Novelty: 0.02220251
p_int: 0.999992356
p_ni: 0.000007644
Score: 0.211
Data Source: BioPlex,STRINGDB
ITM2B
Novelty: 0.00977027
p_int: 0.999685732
p_ni: 0.000314256
p_wrong: 1.2e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
MPPE1
Family: Enzyme
Novelty: 0.16027847
p_int: 0.999673991
p_ni: 0.000325991
p_wrong: 1.8e-8
Score: 0.292
Data Source: BioPlex,STRINGDB
PTCH1
Novelty: 0.00077635
p_int: 0.997783558
p_ni: 0.002141012
p_wrong: 0.00007543
Score: 0.22
Data Source: BioPlex,STRINGDB
EDDM3B
Novelty: 0.12874735
p_int: 0.997122755
p_ni: 0.002876594
p_wrong: 6.51e-7
Data Source: BioPlex
PCDHGA5
Novelty: 2.13631603
p_int: 0.9967279
p_ni: 0.002622376
p_wrong: 0.000649724
Score: 0.152
Data Source: BioPlex,STRINGDB
INSL5
Novelty: 0.04351334
p_int: 0.99663562
p_ni: 0.002914596
p_wrong: 0.000449784
Data Source: BioPlex
MSMB
Novelty: 0.00241546
p_int: 0.99474712
p_ni: 0.005251781
p_wrong: 0.000001099
Data Source: BioPlex
Nearest Tclin Targets
Pathways (79)
Reactome (4)
KEGG (1)
WikiPathways (74)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Other semaphorin interactions | ||||
Reactome | Semaphorin interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Other semaphorin interactions | ||||
Semaphorin interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (2)
Components (4)
Processes (18)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
biological sex | 1 | 1 | 1 | 21.5 | |||||
neuroticism measurement | 1 | 1 | 1 | 4.8 | |||||
1 | 1 | 0 | 1.4 | 1.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
biological sex | 1 | 21.5 | |||||
neuroticism measurement | 1 | 4.8 | |||||
0 | 1.4 | 1.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 6A | VGNC:7151 | 462014 | |||||
Macaque | semaphorin 6A | 697481 | ||||||
Mouse | MGI:1203727 | 20358 | ||||||
Rat | RGD:1305493 | 361324 | ||||||
Dog | semaphorin 6A | VGNC:46001 | 481432 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | semaphorin 6A | |||||
Macaque | semaphorin 6A | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 6A | |||||
Publication Statistics
PubMed Score 151.41
PubMed score by year
PubTator Score 20.89
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
---|