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Tbio
SEMA6A
Semaphorin-6A

Protein Summary
Description
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity). The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343348
  • ENSP00000345512
  • ENSG00000092421
  • ENST00000510263
  • ENSP00000424388

Symbol
  • KIAA1368
  • SEMAQ
  • VIA
  • SEMA
  • HT018
  • SEMAQ
  • SEMA6A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.94
transcription factor binding site profile
0.9
protein domain
0.73
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.41   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.41   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999998934
p_ni:  0.000001066
Data Source:  BioPlex
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999992356
p_ni:  0.000007644
Score:  0.211
Data Source:  BioPlex,STRINGDB
ITM2B
Tbio
Novelty:  0.00977027
p_int:  0.999685732
p_ni:  0.000314256
p_wrong:  1.2e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.999673991
p_ni:  0.000325991
p_wrong:  1.8e-8
Score:  0.292
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.999512341
p_ni:  0.000487651
p_wrong:  8e-9
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.997783558
p_ni:  0.002141012
p_wrong:  0.00007543
Score:  0.22
Data Source:  BioPlex,STRINGDB
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.997122755
p_ni:  0.002876594
p_wrong:  6.51e-7
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.9967279
p_ni:  0.002622376
p_wrong:  0.000649724
Score:  0.152
Data Source:  BioPlex,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.99663562
p_ni:  0.002914596
p_wrong:  0.000449784
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.99474712
p_ni:  0.005251781
p_wrong:  0.000001099
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
1
1
21.5
neuroticism measurement
1
1
1
4.8
1
1
0
1.4
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
21.5
neuroticism measurement
1
4.8
0
1.4
1.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 6A
VGNC:7151
462014
Macaque
semaphorin 6A
697481
Mouse
MGI:1203727
20358
Rat
RGD:1305493
361324
Dog
semaphorin 6A
VGNC:46001
481432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 6A
Macaque
semaphorin 6A
Mouse
Rat
Dog
semaphorin 6A
Publication Statistics
PubMed Score 151.41
PubMed score by year
PubTator Score 20.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title