Tbio SEMA6A Semaphorin-6A

Protein Summary

Description

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity). The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

Uniprot Accession IDs

• Q9H2E6
• Q9P2H9

Gene Name

• SEMA6A

Ensembl ID

• ENST00000343348
• ENSP00000345512
• ENSG00000092421
• ENST00000510263
• ENSP00000424388

Symbol

• KIAA1368
• SEMAQ
• VIA
• SEMA
• HT018
• SEMAQ
• SEMA6A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
transcription factor perturbation	0.94
transcription factor binding site profile	0.9
protein domain	0.73
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-6a

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-6a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.41   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.41   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (117)

Explore Interacting Targets

1 – 10 of 117

• See Interactions on String-DB

NCK1

Tbio

Novelty:  0.00352084

p_int:  0.999998934

p_ni:  0.000001066

Data Source:  BioPlex

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.999992356

p_ni:  0.000007644

Score:  0.211

Data Source:  BioPlex,STRINGDB

ITM2B

Tbio

Novelty:  0.00977027

p_int:  0.999685732

p_ni:  0.000314256

p_wrong:  1.2e-8

Score:  0.189

Data Source:  BioPlex,STRINGDB

MPPE1

Tbio

Family:  Enzyme

Novelty:  0.16027847

p_int:  0.999673991

p_ni:  0.000325991

p_wrong:  1.8e-8

Score:  0.292

Data Source:  BioPlex,STRINGDB

RLN1

Tbio

Novelty:  0.03992636

p_int:  0.999512341

p_ni:  0.000487651

p_wrong:  8e-9

Data Source:  BioPlex

PTCH1

Tbio

Novelty:  0.00077635

p_int:  0.997783558

p_ni:  0.002141012

p_wrong:  0.00007543

Score:  0.22

Data Source:  BioPlex,STRINGDB

EDDM3B

Tdark

Novelty:  0.12874735

p_int:  0.997122755

p_ni:  0.002876594

p_wrong:  6.51e-7

Data Source:  BioPlex

PCDHGA5

Tdark

Novelty:  2.13631603

p_int:  0.9967279

p_ni:  0.002622376

p_wrong:  0.000649724

Score:  0.152

Data Source:  BioPlex,STRINGDB

INSL5

Tbio

Novelty:  0.04351334

p_int:  0.99663562

p_ni:  0.002914596

p_wrong:  0.000449784

Data Source:  BioPlex

MSMB

Tbio

Novelty:  0.00241546

p_int:  0.99474712

p_ni:  0.005251781

p_wrong:  0.000001099

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (79)

Reactome (4)

KEGG (1)

WikiPathways (74)

Axon guidance (R-HSA-422475)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Other semaphorin interactions	19 targets	R-HSA-416700
Reactome	Semaphorin interactions	64 targets	R-HSA-373755

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
Other semaphorin interactions	19 targets	R-HSA-416700
Semaphorin interactions	64 targets	R-HSA-373755

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (2)

Components (4)

Processes (18)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
chemorepellent activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
semaphorin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
biological sex	PATO_0000047	1	1	1		21.5
neuroticism measurement	EFO_0007660	1	1	1		4.8
Granulomatosis with Polyangiitis	EFO_0005297	1	1	0	1.4	1.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
biological sex	PATO_0000047	1		21.5
neuroticism measurement	EFO_0007660	1		4.8
Granulomatosis with Polyangiitis	EFO_0005297	0	1.4	1.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Membrane
Neurogenesis
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
biological sex
Granulomatosis with Polyangiitis
neuroticism measurement

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging
nervous system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	semaphorin 6A	VGNC:7151	462014
Macaque	semaphorin 6A		697481
Mouse	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	MGI:1203727	20358
Rat	semaphorin 6A	RGD:1305493	361324
Dog	semaphorin 6A	VGNC:46001	481432

Species	Name	OMA	EggNOG	Inparanoid
Chimp	semaphorin 6A
Macaque	semaphorin 6A
Mouse	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Rat	semaphorin 6A
Dog	semaphorin 6A

Publication Statistics

PubMed Score 151.41

PubMed score by year

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PubTator Score 20.89

PubTator score by year

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Related Publications

Text Mined References (26)

GeneRif Annotations (11)

Items per page:

10

0 of 0

PMID	Year	Title