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Tbio
TRIOBP
TRIO and F-actin-binding protein

Protein Summary
Description
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403663
  • ENSP00000386026
  • ENSG00000100106
  • ENST00000406386
  • ENSP00000384312
  • ENST00000407319
  • ENSP00000383913
  • ENST00000644935
  • ENSP00000496394
  • ENST00000646328
  • ENSP00000495322

Symbol
  • KIAA1662
  • TARA
  • TARA
  • TAP68
  • DFNB28
  • dJ37E16.4
  • HRIHFB2122
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor perturbation
0.84
transcription factor
0.73
virus perturbation
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.26   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.26   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0