Tbio ARV1 Protein ARV1

Protein Summary

Description

Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892). this gene encodes a transmembrane protein that contains a conserved zinc ribbon motif at the N- terminus. A similar protein in mouse is thought to function in fatty acid homeostasis. Mutations in this gene are associated with early infantile epileptic encephalopathy 38. [provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• Q9H2C2
• A8KAI4
• Q5VSN7
• Q5VSN8
• Q5VSN9
• Q5VSP0
• Q5VSP2
• Q9H2H2
• Q9H5V6
• Q9UFF5
• hARV1

Gene Name

• ARV1

Ensembl ID

• ENST00000310256
• ENSP00000312458
• ENSG00000173409

Symbol

• EIEE38

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
histone modification site profile	0.8
kinase perturbation	0.66
tissue sample	0.62
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.92   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.92   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0